HAS1 抗体
(2 references)Quick Overview for HAS1 抗体 (ABIN969185)
抗原
See all HAS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HAS1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human HAS1 expressed in E. Coli.
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亚型
- IgG1
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anti-Hyaluronan Synthase 1 (HAS1) antibody
HAS1 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5B5B4 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) antibodyHAS1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 74-399) antibodyHAS1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2G5H6 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 501-578) antibodyHAS1 适用: 人, 小鼠, 大鼠 ELISA, FACS, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) antibodyHAS1 适用: 人 WB, ELISA, IHC, IF 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 151-271) antibodyHAS1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 80-390) antibodyHAS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 166-193) antibodyHAS1 适用: 人 WB 宿主: 兔 Polyclonal RB24040 unconjugated
anti-Hyaluronan Synthase 1 (HAS1) (AA 166-193) antibodyHAS1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).
: "Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia." in: Clinical lymphoma, Vol. 5, Issue 4, pp. 253-6, (2005) (PubMed).
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: "Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).
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- HAS1 (Hyaluronan Synthase 1 (HAS1))
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别名
- HAS1
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背景
- Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
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分子量
- 65 kDa
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UniProt
- Q92839
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途径
- Glycosaminoglycan Metabolic Process
抗原
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