BPTF 抗体
(2 references)Quick Overview for BPTF 抗体 (ABIN968990)
抗原
See all BPTF 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- BPTF Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human BPTF expressed in E. Coli.
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亚型
- IgG2b
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anti-Bromodomain PHD Finger Transcription Factor (BPTF) antibody
BPTF 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain PHD Finger Transcription Factor (BPTF) (AA 2801-3046) antibodyBPTF 适用: 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain PHD Finger Transcription Factor (BPTF) antibodyBPTF 适用: 人 DB 宿主: 小鼠 Monoclonal 2343C3a unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).
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: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." in: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
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- BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))
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别名
- BPTF
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背景
- BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level) .Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
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分子量
- 338 kDa
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基因ID
- 2186
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UniProt
- Q12830
抗原
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