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APOE 抗体

This anti-APOE antibody is a 小鼠 单克隆 antibody detecting APOE in ELISA, IHC 和 FACS. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN968962
发货至: 中国

Quick Overview for APOE 抗体 (ABIN968962)

抗原

See all APOE 抗体
APOE (Apolipoprotein E (APOE))

适用

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  • 74
  • 4
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  • 2
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  • 1
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  • 1

宿主

  • 124
  • 45
  • 9
  • 2
  • 1
小鼠

克隆类型

  • 122
  • 58
单克隆

标记

  • 97
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  • 3
  • 3
  • 3
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  • 3
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  • 3
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  • 3
  • 3
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  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This APOE antibody is un-conjugated

应用范围

  • 146
  • 68
  • 60
  • 47
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  • 39
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  • 22
  • 13
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  • 1
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ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

克隆位点

1H4
  • 原理

    ApoE Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human ApoE expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: "Apolipoprotein E gene polymorphism in psoriasis." in: Archives of dermatological research, Vol. 301, Issue 6, pp. 405-10, (2009) (PubMed).

    Zintzaras, Kitsios, Triposkiadis, Lau, Raman: "APOE gene polymorphisms and response to statin therapy." in: The pharmacogenomics journal, Vol. 9, Issue 4, pp. 248-57, (2009) (PubMed).

  • 抗原

    APOE (Apolipoprotein E (APOE))

    别名

    ApoE

    背景

    Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20 % of very low density lipoproteins (VLDL) and 1-2 % of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

    分子量

    36 kDa

    基因ID

    348

    UniProt

    P02649

    途径

    Regulation of Cell Size, Lipid Metabolism
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