ALDH1A1 抗体
(3 references)Quick Overview for ALDH1A1 抗体 (ABIN968955)
抗原
See all ALDH1A1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ALDH1A1 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human ALDH1A1 expressed in E. Coli.
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亚型
- IgG1
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anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 48-147) antibody
ALDH1A1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 2-501) antibodyALDH1A1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (C-Term) antibodyVerified ALDH1A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 1-501) antibodyALDH1A1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) antibodyALDH1A1 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (C-Term) antibodyALDH1A1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 1-110) antibodyALDH1A1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2B2G1 unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 1-326) antibodyALDH1A1 适用: 小鼠 WB, IHC, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 315-434) antibodyALDH1A1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal ALDH1A1-1381 unconjugated
anti-Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) (AA 1-501) antibodyALDH1A1 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 1G6 unconjugated
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells." in: Journal of neuroscience research, Vol. 88, Issue 3, pp. 686-94, (2010) (PubMed).
: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, (2009) (PubMed).
: "Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients." in: Journal of human genetics, Vol. 54, Issue 10, pp. 564-71, (2009) (PubMed).
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: "Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells." in: Journal of neuroscience research, Vol. 88, Issue 3, pp. 686-94, (2010) (PubMed).
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- ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))
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别名
- ALDH1A1
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背景
- ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros. ALDH1A1 is also of interest in Parkinson's Disease (PD) being expressed in the the A9 dopaminergic (DA) neuronal group projecting to the dorsal striatum, this is the most vulnerable site in PD (Chung et al, 2005). ALDH1A1 protein is a known mesencephalic dopaminergic marker. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid .ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea .ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development .The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells.
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分子量
- 55 kDa
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基因ID
- 216
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UniProt
- P00352
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途径
- Dopaminergic Neurogenesis
抗原
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