TSG101 抗体 (AA 229-319)
(3 references)-
- 抗原 See all TSG101 抗体
- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
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抗原表位
- AA 229-319
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TSG101 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠, 犬
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human TSG101 aa. 229-319
- 克隆位点
- 51-TSG101
- 亚型
- IgG1
- Top Product
- Discover our top product TSG101 Primary Antibody
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anti-Tumor Susceptibility Gene 101 (TSG101) (AA 201-280) antibody
TSG101 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 5B7 unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) (AA 4-120) antibodyTSG101 适用: 人, 小鼠, 大鼠, 鱼 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) (Middle Region) antibodyTSG101 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 山羊, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) antibodyTSG101 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) (C-Term) antibodyTSG101 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 山羊, 马, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) antibodyTSG101 适用: 人 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 5B7 unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) antibodyTSG101 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) antibodyTSG101 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) (AA 1-390) antibodyTSG101 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tumor Susceptibility Gene 101 (TSG101) (AA 121-170) antibodyTSG101 适用: 人, 小鼠, 大鼠, 犬, 兔, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968586, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1619-24, (2001) (PubMed).
: "Identification of cellular TSG101 protein in multiple human breast cancer cell lines." in: Cancer research, Vol. 57, Issue 19, pp. 4225-8, (1997) (PubMed).
: "Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells." in: Cell, Vol. 85, Issue 3, pp. 319-29, (1996) (PubMed).
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: "A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1619-24, (2001) (PubMed).
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- 抗原
- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
- 别名
- TSG101 (TSG101 产品)
- 别名
- CG9712 antibody, DmTSG101 antibody, Dmel\\CG9712 antibody, ESCRT-I antibody, Tsg101 antibody, burs antibody, dTSg101 antibody, dTsg101 antibody, dVps23 antibody, ept antibody, tsg101 antibody, vps23 antibody, TSG101 antibody, MGC76193 antibody, TSG10 antibody, VPS23 antibody, AI255943 antibody, CC2 antibody, Rw antibody, zgc:86926 antibody, tumor susceptibility 101 antibody, Tumor susceptibility gene 101 antibody, Tumor Susceptibility Gene homolog antibody, tumor susceptibility gene 101 antibody, tumor susceptibility 101a antibody, tumor susceptibility 101 L homeolog antibody, TSG101 antibody, tsg-101 antibody, tsg101 antibody, Tsg101 antibody, tsg101a antibody, tsg101.L antibody
- 背景
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Tumor Susceptibility Gene 101 (TSG101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. Though the function of TSG101 is not clearly understood, its protein structure includes motifs involved in transcription regulation, and TSG101 has been shown to modulate the activation of steroid hormone receptors. In addition, TSG101 may have a role in regulating ubiquination. The N-terminal region of TSG101 contains a domain that resembles the catalytically active region of ubiquitin conjugases. However, TSG101 lacks an active-site cysteine crucial to the function of these conjugases. Interestingly, TSG101 interferes with MDM2 ubiquination leading to a decrease in MDM2 decay and down-regulation of p53 protein. Thus, TSG101 may function as a dominant-negative inhibitor of ubiquination in pathways where protein expression is tightly regulated.
Synonyms: Tumor Susceptibility Gene 101 - 分子量
- 46 kDa
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