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Tyrosine Hydroxylase 抗体 (AA 18-133)

Name: Tyrosine Hydroxylase 抗体 (AA 18-133)
SKU: ABIN968808
Availability: OutOfStock

This anti-Tyrosine Hydroxylase antibody is a 小鼠单克隆 antibody detecting Tyrosine Hydroxylase in WB 和 IF. Suitable for 大鼠和小鼠. This Primary Antibody has been cited in 2+ publications.

Western blot analysis of Tyrosine Hydroxylase on rat cerebrum lysate. (Tyrosine Hydroxylase 抗体 (AA 18-133))

Immunofluorescence staining of PC12 cells. (Tyrosine Hydroxylase 抗体 (AA 18-133))

2 images

(2 references)

产品编号 ABIN968808

发货至: 中国

Quick Overview for Tyrosine Hydroxylase 抗体 (AA 18-133) (ABIN968808)

抗原

See all Tyrosine Hydroxylase (TH) 抗体

Tyrosine Hydroxylase (TH)

适用

大鼠, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This Tyrosine Hydroxylase antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

45-Tyrosine Hydroxylase

Discover our top product TH Primary Antibody

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AA 18-133

交叉反应

小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Rat Tyrosine Hydroxylase aa. 18-133

亚型

IgG1
anti-Tyrosine Hydroxylase (TH) (AA 101-165) antibody
TH 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (AA 82-310) antibody
TH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (pSer40) antibody
TH 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (pSer31) antibody
TH 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) antibody
TH 适用: 人 WB, IF, ICC, IHC (p), IHC (fro), IHC (wm) 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (AA 486-514) antibody
TH 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (AA 34-301) antibody
TH 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (pSer19) antibody
TH 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (AA 193-222), (Middle Region) antibody
TH 适用: 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Tyrosine Hydroxylase (TH) (C-Term) antibody
Verified TH 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

说明

Related Products: ABIN967389, ABIN968545

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Blanchard-Fillion, Souza, Friel, Jiang, Vrana, Sharov, Barrón, Schöneich, Quijano, Alvarez, Radi, Przedborski, Fernando, Horwitz, Ischiropoulos: "Nitration and inactivation of tyrosine hydroxylase by peroxynitrite." in: The Journal of biological chemistry, Vol. 276, Issue 49, pp. 46017-23, (2001) (PubMed).

Salvatore, Waymire, Haycock: "Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ." in: Journal of neurochemistry, Vol. 79, Issue 2, pp. 349-60, (2001) (PubMed).
抗原

Tyrosine Hydroxylase (TH)

别名

Tyrosine Hydroxylase

背景

Dopamine and its metabolic products norepinephrine and epinephrine are catecholamine neurotransmitters whose function is essential for the execution of normal neural processes in the CNS and PNS. Tyrosine hydroxylase (TH) is a non-heme iron, tetrahydrobiopterin-dependent enzyme that catalzyes the conversion of tyrosine to L-dihydroxyphenylalanine (L-DOPA). This is the rate-limiting step in the biosynthesis of catecholamines. Both the development of Parkinson’s disease and other neurodegenerative diseases result from loss of the ability to synthesize catecholamines. Decreases in the activity of TH have been implicated in these diseases. Nitration of TH at Tyrosine 423 has been associated with temporary loss of enzymatic activity, and TH nitration occurs in response to the Parkinsonian toxin MPTP, and following exposure to peroxynitrite. These findings implicate nitration as a potential mode of down-regulation of TH activity during neurodegenerative disease. Thus, TH is an essential enzyme for catecholamine synthesis, which is required for normal neuronal function.

分子量

58 kDa

途径

Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour