TNIK 抗体 (AA 522-644)
(1 reference)Quick Overview for TNIK 抗体 (AA 522-644) (ABIN968788)
抗原
See all TNIK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 522-644
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交叉反应
- 大鼠, 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human TNIK aa. 522-644
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亚型
- IgG1
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anti-TRAF2 and NCK Interacting Kinase (TNIK) (AA 1-110) antibody
TNIK 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (AA 1-110) antibodyTNIK 适用: 人 ELISA, WB, IP 宿主: 小鼠 Monoclonal 4E4 unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (AA 1-110) antibodyTNIK 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2D2 unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (AA 523-714) antibodyTNIK 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (Ser764) antibodyTNIK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB59089 unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (Internal Region) antibodyTNIK 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 猴, Bat, 小鸡, Hamster IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (Internal Region) antibodyTNIK 适用: 人, 兔, 猴, Bat ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer769) antibodyTNIK 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibodyTNIK 适用: 小鼠, 大鼠 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TRAF2 and NCK Interacting Kinase (TNIK) (AA 1-538) antibodyTNIK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton." in: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 30729-37, (1999) (PubMed).
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: "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton." in: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 30729-37, (1999) (PubMed).
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- TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
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别名
- TNIK
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背景
- Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42 binding domain. Members of the second class lack the GTPase binding sites, but are similar to the former class throughout the catalytic domain. This second class includes germinal center kinase (GCK), HPK, KHS, KRS1 and 2, MST1, 2, and 3, NIK, SOK-1, and TNIK. Traf2- and NCK-interacting kinase (TNIK) is most homologous to another NCK-interacting kinase, NIK. TNIK contains an N- terminal kinase domain, and a C-terminal GCK homology (GCKH) domain. The mRNA of TNIK is expressed highest in heart, brain, and skeletal muscle. Overexpression of TNIK activates the JNK pathway, and leads to the disruption of F-actin structures and the inhibition of cell spreading. In vitro, TNIK can phosphorylate gelsolin. Thus, TNIK is a GCK family kinase that may regulate both the JNK pathway and cytoskeletal dynamics.
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分子量
- 150 kDa
抗原
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