PRSS8 抗体 (AA 108-228)
(4 references)Quick Overview for PRSS8 抗体 (AA 108-228) (ABIN968774)
抗原
See all PRSS8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 108-228
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Prostasin aa. 108-228
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亚型
- IgG2a
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anti-Protease, serine, 8 (PRSS8) (AA 1-343) antibody
PRSS8 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-Protease, serine, 8 (PRSS8) (AA 65-165) antibodyPRSS8 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (AA 185-319) antibodyPRSS8 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (AA 33-131) antibodyPRSS8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (C-Term) antibodyPRSS8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (AA 1-343) antibodyPRSS8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (AA 1-343) antibodyPRSS8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (AA 143-192) antibodyPRSS8 适用: 人, 大鼠, 小鼠, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Protease, serine, 8 (PRSS8) (Middle Region) antibodyPRSS8 适用: 人, 大鼠, 小鼠, 豚鼠, 兔, Cow, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer." in: The Prostate, Vol. 48, Issue 2, pp. 93-103, (2001) (PubMed).
: "Prostasin is a glycosylphosphatidylinositol-anchored active serine protease." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21434-42, (2001) (PubMed).
: "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA." in: The Journal of biological chemistry, Vol. 270, Issue 22, pp. 13483-9, (1995) (PubMed).
: "Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland." in: The Journal of biological chemistry, Vol. 269, Issue 29, pp. 18843-8, (1994) (PubMed).
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: "Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer." in: The Prostate, Vol. 48, Issue 2, pp. 93-103, (2001) (PubMed).
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- PRSS8 (Protease, serine, 8 (PRSS8))
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别名
- Prostasin
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背景
- Prostasin is a serine protease expressed as both GPI-anchored and secreted forms. Prostasin displays trypsin-like enzymatic activity by hydrolyzing substrates, such as D-Pro-Phe-Arg-AMC. This activity is inhibited by aprotinin, antipain, leupeptin, and benzamidine. The highest levels of prostasin protein are found in semen and the prostate, but many other tissues express prostasin at low levels. The sequence of prostasin is similar to other proteases, such as prostase, testisin, plasma kallikrein, and acrosin. In seminal fluid, prostasin can be found in complex with prostasin-binding protein, which can inhibit prostasin enzymatic activity. Prostasin mRNA is found in normal prostate epithelial cells and non-invasive prostate cancer cells, but is not expressed in invasive prostate cancer cell lines. Expression of prostasin in the invasive prostate cancer cell lines, DU-145 and PC-3, reduces the invasiveness of the cells in vitro. Thus, prostasin is a serine protease that may have roles in normal prostate function and in suppression of tumor cell invasion. This antibody is routinely tested by western blot analysis.
抗原
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