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Interleukin enhancer-binding factor 3 (ILF3) (AA 592-695) 抗体

Name: Interleukin enhancer-binding factor 3 (ILF3) (AA 592-695) 抗体
SKU: ABIN968762
Availability: OutOfStock

This anti- antibody is a 小鼠单克隆 antibody detecting in WB 和 IF. Suitable for 人. This Primary Antibody has been cited in 4+ publications.

Western blot analysis of DRBP76 on HeLa lysate. (Interleukin enhancer-binding factor 3 (ILF3) (AA 592-695) 抗体)

Immunofluorescent staining of WI-38 cells at 50 µg/ml. (Interleukin enhancer-binding factor 3 (ILF3) (AA 592-695) 抗体)

2 images

(4 references)

产品编号 ABIN968762

发货至: 中国

Quick Overview for Interleukin enhancer-binding factor 3 (ILF3) (AA 592-695) 抗体 (ABIN968762)

抗原

See all Interleukin enhancer-binding factor 3 (ILF3) 抗体

Interleukin enhancer-binding factor 3 (ILF3)

适用

人

宿主

小鼠

克隆类型

单克隆

标记

非结合性

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

21-DRBP76

Discover our top product ILF3 Primary Antibody

抗原表位
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AA 592-695

产品特性

1. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
4. Please refer to us for technical protocols.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human DRBP76 aa. 592-695

亚型

IgG1
anti-Interleukin enhancer-binding factor 3 (ILF3) (AA 672-891) antibody
ILF3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) (AA 1-270) antibody
ILF3 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) antibody
ILF3 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) (AA 1-702) antibody
ILF3 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) (N-Term) antibody
ILF3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) (AA 785-894) antibody
ILF3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) antibody
ILF3 适用: 人 IHC, ELISA, IF 宿主: 兔 Monoclonal 7H8 unconjugated Recombinant Antibody

anti-Interleukin enhancer-binding factor 3 (ILF3) (AA 41-90) antibody
ILF3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) (AA 23-72) antibody
ILF3 适用: 人, Cow, 犬, 豚鼠, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Interleukin enhancer-binding factor 3 (ILF3) antibody
ILF3 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Saunders, Jurecic, Barber: "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13." in: Genomics, Vol. 71, Issue 2, pp. 256-9, (2001) (PubMed).

Xu, Grabowski: "Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs." in: Molecular genetics and metabolism, Vol. 68, Issue 4, pp. 441-54, (2000) (PubMed).

Buaas, Lee, Edelhoff, Disteche, Braun: "Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 5, pp. 451-6, (1999) (PubMed).

Patel, Vestal, Xu, Bandyopadhyay, Guo, Erme, Williams, Sen: "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20432-7, (1999) (PubMed).
抗原

Interleukin enhancer-binding factor 3 (ILF3)

别名

DRBP76

背景

The double stranded RNA (dsRNA)-dependent, Ser/Thr protein kinase, PKR, is encoded by an IFN-inducible gene and is critical for the anti-viral responses mediated by IFN. Interaction with activators such as heparin, dsRNA, and the dsRNA-binding proteins (DRBPs), DRBP76, PACT, and RAX, induces PKR autophosphorylation and activation. DRBP76 was identified through its binding to dsRNA and PKR. In addition, DRBP76 has been identified as the alternatively spliced nuclear phosphoproteins of 90 kDa (NFAR-1/NF90) and 110 kDa (NFAR-2), as well as M-phase phosphoprotein (MPP4), translational control protein 80 (TCP80), and interleukin enhancer binding factor 3 (ILF3). DRBP76 contains a bi-partite nuclear localization signal at amino acids 369-373 and 386-394, two DRB domains in the C-terminal half, and a C-terminal RG2 domain that is present in many RNA binding proteins. DRBP76 binds pre-mRNAs and spliced mRNAs, co-localizes with PKR in the nucleus, and is phosphorylated by PKR and possibly cyclin-dependent kinases. Thus, DRBP76 may be one of multiple DRBP variants, which associate with PKR and regulate RNA translation. This antibody is routinely tested by western blot analysis.

分子量

90 kDa

途径

M Phase