SRR 抗体 (AA 127-248)
(2 references)Quick Overview for SRR 抗体 (AA 127-248) (ABIN968727)
抗原
See all SRR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 127-248
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交叉反应
- 大鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse serine racemase aa. 127-248
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亚型
- IgG1
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anti-Serine Racemase (SRR) (AA 1-100) antibody
SRR 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Serine Racemase (SRR) (AA 1-340) antibodySRR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Serine Racemase (SRR) (AA 1-340) antibodySRR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Serine Racemase (SRR) (C-Term) antibodySRR 适用: 人, 大鼠, 小鼠, Cow, 犬, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968540, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4926-31, (2000) (PubMed).
: "Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13409-14, (1999) (PubMed).
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: "D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4926-31, (2000) (PubMed).
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- SRR (Serine Racemase (SRR))
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别名
- Serine Racemase
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背景
- The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5' phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission. This antibody is routinely tested by western blot analysis.
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分子量
- 38 kDa
抗原
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