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MTTP 抗体 (AA 91-288)

MTTP 适用: 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 8-MTP unconjugated
产品编号 ABIN968716
发货至: 中国
  • 抗原 See all MTTP 抗体
    MTTP (Microsomal Triglyceride Transfer Protein (MTTP))
    抗原表位
    • 11
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 91-288
    适用
    • 40
    • 16
    • 12
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠, 大鼠
    宿主
    • 39
    • 2
    小鼠
    克隆类型
    • 42
    单克隆
    标记
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTTP antibody is un-conjugated
    应用范围
    • 29
    • 21
    • 20
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse MTP aa. 91-288
    克隆位点
    8-MTP
    亚型
    IgG2a
    Top Product
    Discover our top product MTTP Primary Antibody
  • 说明

    Related Products: ABIN968543, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Chen, Newberry, Norris, Xie, Luo, Kennedy, Davidson: "ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice." in: Journal of lipid research, Vol. 49, Issue 9, pp. 2013-22, (2008) (PubMed).

    Qin, Anderson, Adeli: "Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 5, pp. G1120-9, (2008) (PubMed).

    Morral, Edenberg, Witting, Altomonte, Chu, Brown: "Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver." in: Journal of lipid research, Vol. 48, Issue 7, pp. 1499-510, (2007) (PubMed).

    Read, Anderson, Ritchie, Vanloo, Amey, Levitt, Rosseneu, Scott, Shoulders: "A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein." in: The Journal of biological chemistry, Vol. 275, Issue 39, pp. 30372-7, (2000) (PubMed).

    Wetterau, Gregg, Harrity, Arbeeny, Cap, Connolly, Chu, George, Gordon, Jamil, Jolibois, Kunselman, Lan, Maccagnan, Ricci, Yan, Young, Chen, Fryszman, Logan, Musial, Poss, Robl, Simpkins, Slusarchyk et al.: "An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. ..." in: Science (New York, N.Y.), Vol. 282, Issue 5389, pp. 751-4, (1998) (PubMed).

    Nakamuta, Chang, Hoogeveen, Li, Chan: "Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression and chromosomal localization." in: Genomics, Vol. 33, Issue 2, pp. 313-6, (1997) (PubMed).

  • 抗原
    MTTP (Microsomal Triglyceride Transfer Protein (MTTP))
    别名
    MTP (MTTP 产品)
    别名
    ABL antibody, MTP antibody, 1810043K16Rik antibody, CG9342 antibody, CT3751 antibody, Dmel\\CG9342 antibody, dMTP antibody, wu:fd36b01 antibody, zgc:111876 antibody, microsomal triglyceride transfer protein antibody, Microsomal triacylglycerol transfer protein antibody, MTTP antibody, Mttp antibody, Mtp antibody, mttp antibody
    背景
    The microsomal triglyceride transfer protein (MTP) catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between membranes within the lumen of microsomes in hepatocytes and enterocytes. MTP forms a heterodimer with the 58 kDa protein disulfide isomerase. PDI catalyzes the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configuration within proteins. MTP is mutated in abetalipoproteinemia, which results from defects in apolipoprotein-B (apoB)-containing lipoproteins. A lack of MTP expression prevents secretion of apoB from mammalian cells, leading to intracellular degradation. In the C-terminal region, MTP has structural homology to apoB and the lamprey lipovitellin protein. This region contains a membrane binding helix (Helix A), and a triglyceride binding helix (Helix B). Mutations in Helix B cause abetalipoproteinemia. In addition, inhibitors of MTP activity may be important therapeutics for lowering atherogenic lipoprotein levels. Thus, MTP is a microsomal protein that is required for transport of lipids between membranes in liver and small intestines.
    Synonyms: Microsomal Triglyceride transfer Protein
    分子量
    97 kDa
    途径
    Transition Metal Ion Homeostasis
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