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COMT 抗体 (AA 26-141)

Name: COMT 抗体 (AA 26-141)
SKU: ABIN968704
Availability: OutOfStock

This 小鼠单克隆 antibody specifically detects COMT in WB, IF 和 BI. It exhibits reactivity toward 大鼠和小鼠. It has been mentioned in 3+ publications

Western Blotting (WB) image for anti-Catechol-O-Methyltransferase (COMT) (AA 26-141) antibody (ABIN968704) (COMT 抗体 (AA 26-141))

Immunofluorescence (IF) image for anti-Catechol-O-Methyltransferase (COMT) (AA 26-141) antibody (ABIN968704) (COMT 抗体 (AA 26-141))

Western blot analysis of COMT on a rat pituitary lysate. (COMT 抗体 (AA 26-141))

Immunofluorescence staining of rat cortical neurons. (COMT 抗体 (AA 26-141))

4 images

(3 references)

产品编号 ABIN968704

发货至: 中国

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Quick Overview for COMT 抗体 (AA 26-141) (ABIN968704)

抗原

See all COMT 抗体

COMT (Catechol-O-Methyltransferase (COMT))

适用

大鼠, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This COMT antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)

克隆位点

4-COMT

Discover our top product COMT Primary Antibody

抗原表位
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AA 26-141

交叉反应

大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Mouse COMT aa. 26-141

亚型

IgG1
anti-Catechol-O-Methyltransferase (COMT) (Internal Region) antibody
Verified COMT 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (N-Term) antibody
Verified COMT 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) antibody
KO Validated COMT 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 52-271) antibody
COMT 适用: 人, 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 1-182) antibody
COMT 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G4-1A1 unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 52-271) antibody
COMT 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (Internal Region) antibody
COMT 适用: 人, 大鼠, 小鼠, 猴, Cow, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (C-Term) antibody
COMT 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) antibody
KD Validated COMT 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3735 unconjugated Recombinant Antibody

anti-Catechol-O-Methyltransferase (COMT) (AA 1-221) antibody
COMT 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Werner, Di Rocco, Prikhojan, Rempel, Bottiglieri, Bressman, Yahr: "COMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitro." in: Brain research, Vol. 893, Issue 1-2, pp. 278-81, (2001) (PubMed).

Gogos, Morgan, Luine, Santha, Ogawa, Pfaff, Karayiorgou: "Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 17, pp. 9991-6, (1998) (PubMed).

Tilgmann, Melen, Lundström, Jalanko, Julkunen, Kalkkinen, Ulmanen: "Expression of recombinant soluble and membrane-bound catechol O-methyltransferase in eukaryotic cells and identification of the respective enzymes in rat brain." in: European journal of biochemistry / FEBS, Vol. 207, Issue 2, pp. 813-21, (1992) (PubMed).
抗原

COMT (Catechol-O-Methyltransferase (COMT))

别名

COMT

背景

Catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) are the major mammalian enzymes involved in the degradation of the catecholamine neurotransmitters, dopamine, norepinephrine, and epinephrine. COMT is a Mg2+-dependent enzyme that catalyzes the transfer of methyl groups from S-adenosyl methionine to a hydroxyl group of a catecholic substrate. Two forms of COMT are found in rat brain, a 24 kDa soluble COMT (S-COMT) and a 28 kDa membrane-bound COMT (MB-COMT). COMT is widely expressed in brain, but its importance in catecholamine neurotransmitter degradation relative to MAO varies in different brain regions. In addition, COMT may function primarily in extraneuronal areas, such as in glial cells and postsynaptic neurons. COMT-deficient mice have sex- and region-specific alterations in dopamine levels in the brain, and display impaired emotional reactivity and aggressive behavior. Thus, COMT-mediated degradation of catecholamines in the brain may have important roles in maintaining normal catecholamine levels, as well as normal social behavior. This antibody is routinely tested by western blot analysis.
Synonyms: Catechol-O-Methyltransferase

分子量

24/28 kDa

途径

Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome