NLRP2 抗体 (AA 620-732)
Quick Overview for NLRP2 抗体 (AA 620-732) (ABIN968688)
抗原
See all NLRP2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 620-732
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交叉反应
- 小鼠, 大鼠, 犬, 小鸡
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human NBS1 aa. 620-732
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亚型
- IgG1
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anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-1062) antibody
NLRP2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-220) antibodyNLRP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (C-Term) antibodyNLRP2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-220) antibodyNLRP2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (C-Term) antibodyVerified NLRP2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-846) antibodyNLRP2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1B10 unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 1-1062) antibodyNLRP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) (AA 150-200) antibodyNLRP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 2 (NLRP2) antibodyNLRP2 适用: 人, 小鼠, Hamster, 猴 WB, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968537, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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- NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
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别名
- NBS1
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背景
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Nijmegen Breakage Syndrome (NBS) is characterized by extreme radiation sensitivity and chromosomal instability. The NBS1 gene product, p95/nibrin/NBS1, forms a complex with Rad50 and Mre11. Cells deficient in this complex have problems with DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. NBS1 contains a forkhead-associated domain (FHA) and a breast cancer carboxy-terminal domain (BRCT) in the N-terminal region. Both of these domains have been found in DNA-damage responsive cell cycle checkpoint proteins. The complex containing NBS1, Rad50, and Mre11 possesses manganese-dependent single stranded DNA endonuclease and 3' to 5' exonuclease activities. In addition, NBS1 is required for DNA-damage dependent phosphorylation of Mre11. This phosphorylation may be required for proper nuclear localization of the NBS1-Rad50-Mre11 complex to sites of DNA double-strand breaks. NBS1 interacts directly with telomere repeat binding factor, TRF1, via its C-terminal region, and both NBS1 and Mre11 co-localize with TRF1 at promyelocytic leukemia nuclear bodies. Thus, the NBS1-Rad50-Mre11 complex may be important for both DNA damage repair, and telomere length maintenance.
Synonyms: Nijmegen Breakage Syndrome-1 -
分子量
- 95 kDa
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途径
- Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
抗原
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