ARHGAP5 抗体 (AA 1102-1214)
(2 references)Quick Overview for ARHGAP5 抗体 (AA 1102-1214) (ABIN968611)
抗原
See all ARHGAP5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1102-1214
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交叉反应
- 大鼠, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human p190-B aa. 1102-1214
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亚型
- IgG1
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anti-rho GTPase Activating Protein 5 (ARHGAP5) (AA 1292-1501) antibody
ARHGAP5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-rho GTPase Activating Protein 5 (ARHGAP5) antibodyARHGAP5 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-rho GTPase Activating Protein 5 (ARHGAP5) antibodyARHGAP5 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-rho GTPase Activating Protein 5 (ARHGAP5) (Internal Region) antibodyARHGAP5 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho GTPase Activating Protein 5 (ARHGAP5) (N-Term) antibodyARHGAP5 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968533, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene." in: Biochimica et biophysica acta, Vol. 1443, Issue 1-2, pp. 203-10, (1999) (PubMed).
: "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking." in: The Journal of biological chemistry, Vol. 270, Issue 52, pp. 30919-26, (1996) (PubMed).
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: "Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene." in: Biochimica et biophysica acta, Vol. 1443, Issue 1-2, pp. 203-10, (1999) (PubMed).
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- ARHGAP5 (rho GTPase Activating Protein 5 (ARHGAP5))
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别名
- p190-B
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背景
- GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21ras and Rho. p190-A is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190-A are targets of oncoproteins and growth factor receptors. p190-B is another Ras-GAP in the p190 family. It has 51% identity with p190-A and contains several GTPase-related domains in the N-terminal region and a Rho-GAP domain in the C-terminal region. p190-B is expressed in kidney, brain, liver, and lung, as well as in human foreskin fibroblasts, RD muscle cells, and HT-1080 cells. In fibroblasts, p190-B is localized diffusely in the cytoplasm and co-localizes with the alpha5beta1 integrin receptor for fibronectin. Adhesion of fibronectin-coated latex beads to cells leads to the recruitment of p190-B and Rho to the plasma membrane at sites of bead contact. In addition, the recombinant Rho-GAP domain of p190-B displays GAP activity for RhoA, Rac1, and G25K/CDC42Hs. Thus, p190-B is thought to act as a transmembrane link between integrins and Rho GTPases during fibronectin-induced changes in cell morphology and motility.
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分子量
- 190 kDa
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途径
- Regulation of Cell Size
抗原
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