SOD2 抗体 (AA 114-220)
(5 references)Quick Overview for SOD2 抗体 (AA 114-220) (ABIN968602)
抗原
See all SOD2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 114-220
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交叉反应
- 人, 犬, 大鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse MnSOD aa. 114-220
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亚型
- IgG1
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anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 25-222) antibody
SOD2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 25-222) antibodySOD2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) antibodySOD2 适用: 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 1-222) antibodySOD2 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 8H3D2 unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 1-222) antibodySOD2 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 8H3F9 unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 41-78) antibodySOD2 适用: 人, 小鼠, Pig, 绵羊 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 25-222) antibodySOD2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 64-175) antibodySOD2 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) antibody (PE)SOD2 适用: 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal PE
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) antibody (PerCP)SOD2 适用: 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal PerCP
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说明
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Related Products: ABIN968542, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate." in: The Journal of biological chemistry, Vol. 274, Issue 52, pp. 37455-60, (2000) (PubMed).
: "Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer." in: Cancer research, Vol. 59, Issue 3, pp. 602-6, (1999) (PubMed).
: "Antioxidant gene expression in rat lung after exposure to cigarette smoke." in: The American journal of pathology, Vol. 152, Issue 1, pp. 269-78, (1998) (PubMed).
: "Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 6, pp. 2040-55, (1998) (PubMed).
: "Alterations of antioxidant enzyme expression in response to hydrogen peroxide." in: Free radical biology & medicine, Vol. 24, Issue 1, pp. 27-38, (1998) (PubMed).
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: "Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate." in: The Journal of biological chemistry, Vol. 274, Issue 52, pp. 37455-60, (2000) (PubMed).
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- SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))
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别名
- MnSOD
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背景
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Superoxide dismutase (SOD), catalase, and glutathione peroxidase are necessary for preventing the intracellular accumulation of reactive oxygen species. Three forms of SOD include the cytosolic Cu/Zn2+ SOD, the extracelluar Cu/Zn[2+] SOD, and the mitochondrial manganese (Mn) superoxide dismutase (MnSOD). In the mitochondria, MnSOD catalyzes the dismutation of two superoxide radicals, producing H2O2 and oxygen. Following protein synthesis, MnSOD is post-transcriptionally modified for transport from the cytosol into the mitochondria. In rat hepatocytes, H2O2 exposure induces MnSOD expression, while in rat lung, exposure to smoke induces expression in bronchial epithelial cells. In addition, MnSOD expression is required for PC12 cell resistance to nitric oxide (NO) toxicity and for nNOS neuron resistance to NMDA-induced NO toxicity. Superoxide radical anions may induce transcriptional activation of the MnSOD gene through PKC phosphorylation and activation of a CREB-1/ATF-1-like factor. Thus, MnSOD removal of reactive oxygen species created by exposure to toxic stimuli is thought to be critical for the survival of a variety of cell types. This antibody is routinely tested by western blot analysis.
Synonyms: Manganese Superoxide Dismutase -
分子量
- 25 kDa
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途径
- Sensory Perception of Sound, Transition Metal Ion Homeostasis, Negative Regulation of intrinsic apoptotic Signaling
抗原
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