MPDZ 抗体 (AA 65-247)
(2 references)Quick Overview for MPDZ 抗体 (AA 65-247) (ABIN968588)
抗原
See all MPDZ 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 65-247
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交叉反应
- 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Rat MUPP1 aa. 65-247
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亚型
- IgG1
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anti-Multiple PDZ Domain Protein (MPDZ) (Middle Region) antibody
MPDZ 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Multiple PDZ Domain Protein (MPDZ) (AA 1691-1740) antibodyMPDZ 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Multiple PDZ Domain Protein (MPDZ) (AA 1100-1380) antibodyMPDZ 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN967389, ABIN968545
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).
: "Cloning and characterization of MUPP1, a novel PDZ domain protein." in: FEBS letters, Vol. 424, Issue 1-2, pp. 63-8, (1998) (PubMed).
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: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).
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- MPDZ (Multiple PDZ Domain Protein (MPDZ))
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别名
- MUPP1
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背景
- The postsynaptic density protein PSD-95 interacts with the cytoplasmic tail of ion channel subunits via a protein-protein motif called the PDZ domain. PSD-95 belongs to a family of PDZ domain-containing proteins that includes SAP97/Dlg, PSD-93/chapsyn-110, and SAP102. These proteins are characterized by three PDZ domains in the N-terminal half and an SH3 and guanylate kinase-like domain in the C-terminal region. They may be involved in the localization and clustering of ion channels and receptors at synaptic sites. Other PDZ domain-containing proteins such as glutamate receptor interacting protein (GRIP), Homer, and multi-PDZ-domain protein (MUPP1) do not contain guanylate kinase-like domains, but have also been implicated in receptor localization. MUPP1 contains thirteen PDZ domains and is expressed in human heart, brain, placenta, liver, skeletal muscle, kidney, and pancreas. In addition, smaller variants of MUPP1 are expressed in heart, liver, kidney, and brain. The C-terminal region of the 5-HT2c receptor interacts with MUPP1, suggesting that MUPP1 may have important protein-protein interactions during G-protein coupled receptor signaling.
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分子量
- 219 kDa
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途径
- Synaptic Membrane, Phototransduction
抗原
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