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FUS 抗体 (AA 2-117)

Name: FUS 抗体 (AA 2-117)
SKU: ABIN968509
Availability: OutOfStock

This anti-FUS antibody is a 小鼠单克隆 antibody detecting FUS in WB 和 IF. Suitable for 人和大鼠. This Primary Antibody has been cited in 5+ publications.

Western Blotting (WB) image for anti-Fused in Sarcoma (FUS) (AA 2-117) antibody (ABIN968509) (FUS 抗体 (AA 2-117))

Image no. 1 for anti-Fused in Sarcoma (FUS) (AA 2-117) antibody (ABIN968509) (FUS 抗体 (AA 2-117))

Western blot analysis of TLS on a Jurkat cell lysate. (FUS 抗体 (AA 2-117))

3 images

(5 references)

产品编号 ABIN968509

发货至: 中国

Quick Overview for FUS 抗体 (AA 2-117) (ABIN968509)

抗原

See all FUS 抗体

FUS (Fused in Sarcoma (FUS))

适用

人, 大鼠

宿主

小鼠

克隆类型

单克隆

标记

This FUS antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

15-TLS

Discover our top product FUS Primary Antibody

抗原表位
15

7

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2

2

2

1

1

1

1

1
AA 2-117

交叉反应

大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human TLS aa. 2-117.

亚型

IgG1
anti-Fused in Sarcoma (FUS) (N-Term) antibody
FUS 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (AA 499-526) antibody
FUS 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (AA 297-526) antibody
FUS 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (AA 1-198) antibody
FUS 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (N-Term) antibody
FUS 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (N-Term) antibody
FUS 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (AA 499-526), (C-Term) antibody
FUS 适用: 人, 小鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB23928 unconjugated

anti-Fused in Sarcoma (FUS) (AA 506-534), (C-Term) antibody
FUS 适用: 人, 小鼠 WB, IF, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (AA 421-526) antibody
FUS 适用: 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fused in Sarcoma (FUS) (C-Term) antibody
FUS 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968537, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Hallier, Lerga, Barnache, Tavitian, Moreau-Gachelin: "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS." in: The Journal of biological chemistry, Vol. 273, Issue 9, pp. 4838-42, (1998) (PubMed).

Morohoshi, Ootsuka, Arai, Ichikawa, Mitani, Munakata, Ohki: "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes." in: Gene, Vol. 221, Issue 2, pp. 191-8, (1998) (PubMed).

Powers, Mathur, Raaka, Ron, Samuels: "TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors." in: Molecular endocrinology (Baltimore, Md.), Vol. 12, Issue 1, pp. 4-18, (1998) (PubMed).

Yang, Embree, Tsai, Hickstein: "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 27761-4, (1998) (PubMed).

Zinszner, Sok, Immanuel, Yin, Ron: "TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling." in: Journal of cell science, Vol. 110 ( Pt 15), pp. 1741-50, (1997) (PubMed).
抗原

FUS (Fused in Sarcoma (FUS))

别名

TLS

背景

Chromosomal translocations in leukemias and malignancies of non-hematopoietic tissues usually result in the fusion of genes and the production of novel fusion proteins. Translocated in liposarcoma (TLS/FUS) was identified through its fusion to the transcription factor CHOP in human myxoid liposarcoma. In addition, the fusion of TLS to the transcription factor ERG is involved in human acute myeloid leukemia. TLS contains an N-terminal Gln-, Ser-, and Tyr-rich region (QSY) that is thought to be a potent transactivator when fused with transcription factors. In its C-terminus, TLS contains a ribonucleoprotein consensus sequence (RNP-CS) and Arg-Gly-Gly (RGG) repeats that have been implicated in RNA binding. This feature allows it to function in shuttling of RNA from the nucleus. TLS also interacts with Ser-Arg proteins that regulate RNA splicing. Interestingly, TLS also interacts with the DNA binding domains of the estrogen, thyroid hormone, and glucocorticoid receptors. Thus, TLS is a multifunctional protein that is involved in RNA transport, nuclear receptor function, and gene transactivation when fused with transcription factors. This antibody is routinely tested by western blot analysis.

分子量

65 kDa