NPAT 抗体 (AA 681-803)
This anti-NPAT antibody is a 小鼠 单克隆 antibody detecting NPAT in WB 和 IF. Suitable for 人. This Primary Antibody has been cited in 1 publication.
(1 reference)Quick Overview for NPAT 抗体 (AA 681-803) (ABIN968484)
抗原
See all NPAT 抗体
NPAT
(Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This NPAT antibody is un-conjugated
应用范围
Western Blotting (WB), Immunofluorescence (IF)
克隆位点
27-NPAT
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抗原表位
- AA 681-803
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human NPAT aa. 681-803
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亚型
- IgG2b
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anti-Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT) antibody
NPAT 适用: 人 DB 宿主: 小鼠 Monoclonal 2648C6a unconjugated
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说明
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Related Products: ABIN968537, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry." in: Genes & development, Vol. 12, Issue 4, pp. 456-61, (1998) (PubMed).
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: "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry." in: Genes & development, Vol. 12, Issue 4, pp. 456-61, (1998) (PubMed).
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- NPAT (Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT))
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别名
- NPAT
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背景
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Cyclins regulate transitions between cell cycle phases by acting as regulatory subunits of the cyclin-dependent kinases (cdk). The temporal expression of cyclins is tightly regulated and plays a critical role in controlling the enzymatic activity of the cdks. Cyclin-dependent kinase 2 (Cdk2) is a member of a family of cdc2-related cell cycle protein kinases. Cdk2 is expressed earlier in the cell cycle than cdc2 and forms complexes with cyclins A, E, D1, and D3. It is not known if the D cyclins can form active complexes with Cdk2. Cyclin E-Cdk2 kinase is active in the G1 and S phases of the cell cycle and is important, as is Cyclin A-Cdk2, for the progression from G1 to S phase. One substrate for cyclin E-Cdk2 is a Nuclear Protein mapped to the Ataxia Telangiectasia locus, NPAT. This protein associates with cyclin E-Cdk2 and can be phosphorylated by Cdk2. NPAT protein levels peak at the G1/S boundary and overexpression of NPAT accelerates S phase entry, especially after coexpression of cyclin E-Cdk2. Thus, NPAT is a substrate of cyclin E-Cdk2 that may mediate G1 to S phase transition.
Synonyms: Nuclear Protein Ataxia Telangiectasia -
分子量
- 210 kDa
抗原
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