STXBP5 抗体 (AA 910-1105)
(2 references)Our Local Distributor
北京 101111
Quick Overview for STXBP5 抗体 (AA 910-1105) (ABIN968460)
抗原
See all STXBP5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 910-1105
-
交叉反应
- 小鼠, 人
-
产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
免疫原
- Rat Tomosyn aa. 910-1105
-
亚型
- IgG1
-
-
anti-Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) (AA 515-610) antibody
STXBP5 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) (AA 1067-1139) antibodySTXBP5 适用: 人, 大鼠, 小鼠, Cow WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin Binding Protein 5 (Tomosyn) (STXBP5) (AA 1017-1115) antibodySTXBP5 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
-
-
说明
-
Related Products: ABIN968545, ABIN967389
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 250 μg/mL
-
缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store undiluted at -20°C.
-
-
-
: "Three splicing variants of tomosyn and identification of their syntaxin-binding region." in: Biochemical and biophysical research communications, Vol. 256, Issue 1, pp. 218-22, (1999) (PubMed).
: "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process." in: Neuron, Vol. 20, Issue 5, pp. 905-15, (1998) (PubMed).
-
: "Three splicing variants of tomosyn and identification of their syntaxin-binding region." in: Biochemical and biophysical research communications, Vol. 256, Issue 1, pp. 218-22, (1999) (PubMed).
-
- STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))
-
别名
- Tomosyn
-
背景
- Neuronal signal transmission and neurotransmitter release from the presynaptic nerve terminal is mediated by the synaptic vesicle cycle. Syntaxin plays a central role during vesicle docking and fusion through interactions with many vesicle components. During docking, vSNAREs (VAMP/synaptobrevin, synaptotagmin) on the synaptic vesicle and tSNAREs (SNAP-25, syntaxin) on the plasma membrane interact to form a 7S complex, which is essential to docking and fusion. Syntaxin associates with munc18/n-sec1 prior to and/or during the formation of the 7S complex. This interaction may inhibit syntaxin binding proteins (VAMP, SNAP-25) that facilitate vesicle docking or fusion. Tomosyn, a syntaxin binding protein, displaces munc18 from syntaxin-1 and forms a novel 10S complex with syntaxin-1, SNAP-25, and synaptogamin. There are two splice variants of tomosyn designated b-tomosyn and s-tomosyn, while the original is referred to as m-tomosyn. Although b-tomosyn is ubiquitously expressed, s-tomosyn and m-tomosyn are expressed primarily in brain. This antibody is routinely tested by western blot analysis.
-
分子量
- 130 kDa
抗原
-
