Aldehyde Dehydrogenase 抗体 (AA 7-128)
There are 4+ publications for this product available. The 小鼠 单克隆 anti-Aldehyde Dehydrogenase antibody is suitable to detect Aldehyde Dehydrogenase in samples from 人. It has been validated for WB, IF 和 IHC.
(4 references)
产品编号 ABIN968411
发货至:
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Quick Overview for Aldehyde Dehydrogenase 抗体 (AA 7-128) (ABIN968411)
抗原
See all Aldehyde Dehydrogenase (ALDH) 抗体
Aldehyde Dehydrogenase (ALDH)
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This Aldehyde Dehydrogenase antibody is un-conjugated
应用范围
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
克隆位点
44-ALDH
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抗原表位
- AA 7-128
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human ALDH1 aa. 7-128
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亚型
- IgG1
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说明
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Related Products: ABIN967389, ABIN968533
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma." in: Head & neck, Vol. 35, Issue 4, pp. 575-8, (2013) (PubMed).
: "The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7030-7, (1998) (PubMed).
: "Human aldehyde dehydrogenase gene family." in: European journal of biochemistry / FEBS, Vol. 251, Issue 3, pp. 549-57, (1998) (PubMed).
: "Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase." in: Biochemical and biophysical research communications, Vol. 236, Issue 2, pp. 527-31, (1997) (PubMed).
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: "ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma." in: Head & neck, Vol. 35, Issue 4, pp. 575-8, (2013) (PubMed).
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- Aldehyde Dehydrogenase (ALDH)
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别名
- ALDH
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背景
- Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues. It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids. There are multiple isoforms of ALDH which are subdivided into three classes. Class I includes the cytosolic isoforms. Class II includes the mitochondrial isoforms. Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms. At least twelve human ALDH isoforms have been identified. Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities. At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%). However, multiple protein regions have been highly conserved and are important for functional activities. A well-characterized member of the human ALDH family is ALDH1. It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A). Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival.
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分子量
- 55 kDa
抗原
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