BIRC6 抗体 (AA 372-571)
(1 reference)Quick Overview for BIRC6 抗体 (AA 372-571) (ABIN968409)
抗原
See all BIRC6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 372-571
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交叉反应
- 人, 大鼠, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse BRUCE aa. 372-571
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亚型
- IgG1
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anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) antibody
BIRC6 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) (AA 4810-4844) antibodyBIRC6 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB56699 unconjugated
anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) (AA 4701-4857) antibodyBIRC6 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) (C-Term) antibodyVerified BIRC6 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) (AA 4576-4857) antibodyBIRC6 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Clone 4/BRUCE has also been shown to work well for Western blot application on Hela lysate (ABIN968535)
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说明
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Related Products: ABIN968552, ABIN967389, ABIN968535
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors." in: The Journal of cell biology, Vol. 141, Issue 6, pp. 1415-22, (1998) (PubMed).
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: "A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors." in: The Journal of cell biology, Vol. 141, Issue 6, pp. 1415-22, (1998) (PubMed).
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- BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))
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别名
- BRUCE
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背景
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Selective proteolysis is essential for the modulation of key cellular processes such as cell cycle progression. However, unlike other post-translational events, proteolysis is irreversible and therefore must occur in unidirectional cellular pathways. In eukaryotes, proteolysis is mediated primarily by the ubiquitin pathway. This pathway designates proteins for degradation by the proteasome, a multicatalytic protease complex. The ubiquitin pathway is a multistep system that tags proteins for degradation via the attachment of ubiquitin molecules to the target. This attachment is mediated by the ubiquitin activating/conjugating enzymes E1, E2, E3, and BRUCE. BRUCE (BIR Repeat containing Ubiquitin-Conjugating Enzyme) is a novel enzyme that associates with the Golgi and the vesicular system. It contains a UBC (ubiquitin conjugating enzyme) domain, which is essential for catalysis, and a BIR (baculovirus inhibitor of apoptosis repeat) motif. BIR motifs are also found within inhibitor of apoptosis proteins (IAP) and are critical for anti-apoptotic activity. Therefore, BRUCE may function to both mediate ubiquitin-dependent proteolysis and contribute to anti-apoptotic cellular pathways.
Synonyms: BIR Repeat containing Ubiquitin-Conjugating Enzyme -
分子量
- 528 kDa
抗原
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