G3BP1 抗体 (AA 210-323)
(2 references)Quick Overview for G3BP1 抗体 (AA 210-323) (ABIN968381)
抗原
See all G3BP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 210-323
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human G3BP aa. 210-323
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亚型
- IgG1
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anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 214-303) antibody
G3BP1 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2F3 unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 1-466) antibodyG3BP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (N-Term) antibodyG3BP1 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, Cow, 兔 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 131-330) antibodyG3BP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) antibodyG3BP1 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 227-466) antibodyG3BP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (pSer232) antibodyG3BP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 136-185) antibodyG3BP1 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, Cow, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (AA 1-466) antibodyG3BP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1) (Center) antibodyG3BP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968552, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability." in: Molecular and cellular biology, Vol. 18, Issue 7, pp. 3956-65, (1998) (PubMed).
: "A Ras-GTPase-activating protein SH3-domain-binding protein." in: Molecular and cellular biology, Vol. 16, Issue 6, pp. 2561-9, (1996) (PubMed).
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: "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability." in: Molecular and cellular biology, Vol. 18, Issue 7, pp. 3956-65, (1998) (PubMed).
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- G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))
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别名
- G3BP
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背景
- The Ras proteins are low molecular weight GTPases that play a critical role in the control of proliferation, differentiation, and cytoskeletal organization. RasGAP acts as a negative regulator of Ras, as well as a downstream target of Ras. It participates in the signal transduction cascade through interactions with other signaling proteins. Via its C-terminal domain, RasGAP interacts with Ras, but the N-terminus interacts with other signaling molecules such as p62 and p190. This function of RasGAP is mediated by the presence of SH2, SH3, and PH domains in the N-terminal region. However, some signaling proteins cannot bind to these domains. In an attempt to identify RasGAP-interacting molecules, a GAP SH3-Binding Protein (G3BP) was identified. This protein exhibits sequence homology to the hnRNP superfamily. It contains RNP1 and RNP2 motifs and is found primarily in the cytosol. G3BP interacts with GAP in proliferating cells and is dependent on the activation state of Ras. In addition, G3BP contains an intrinsic endonuclease activity that cleaves 3'-untranslated region (3'-UTR) mRNA. These data indicate that G3BP may link the Ras pathway to mRNA degradation.
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分子量
- 55-70 kDa
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途径
- SARS-CoV-2 Protein Interactome
抗原
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