CD38 抗体 (AA 171-292)
(2 references)Quick Overview for CD38 抗体 (AA 171-292) (ABIN968373)
抗原
See all CD38 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 171-292
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human CD38 aa. 171-292
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亚型
- IgG1
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anti-CD38 (AA 1-300) antibody
适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CD38 (AA 46-300) antibody适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CD38 (AA 43-300) antibody适用: 人 IHC, WB, ELISA 宿主: 小鼠 Monoclonal 5C5C3 unconjugated
anti-CD38 (AA 241-270), (C-Term) antibody适用: 人 FACS, WB, IF, IHC (p) 宿主: 兔 Polyclonal RB18001 unconjugated
anti-CD38 (AA 241-270) antibody适用: 人 FACS, IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CD38 (Internal Region) antibody适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD38 antibody适用: 人 FACS, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal HIT2 unconjugated
anti-CD38 antibody (APC)适用: 人 FACS 宿主: 小鼠 Monoclonal HIT2 APC
anti-CD38 antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal HIT2 PE
anti-CD38 (AA 101-200) antibody适用: 小鼠, 大鼠 FACS, WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN967389, ABIN968584
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, (1998) (PubMed).
: "Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4702-8, (1998) (PubMed).
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: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, (1998) (PubMed).
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- CD38
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背景
- Lymphocyte trafficking is essential for efficient immune responses in that it allows antigen sensitive lymphocytes to encounter antigen and be recruited to sites of infection. Trafficking involves the passage of lymphocytes across the HEV, a process that is mediated by selectins. CD38 is a single-chain type II transmembrane glycoprotein that is expressed by a variety of immature and activated lymphocytes. It mediates a selectin-like binding to endothelial cells, thus functioning as an adhesion molecule. Human and mouse forms of the protein are highly similar and homologous to the Aplysia californica ADP-ribosyl-cyclase. CD38 catalyzes the synthesis of cyclic ADP-ribose (cADPR), a putative endogenous regulator of calcium release. This is thought to be key to CD38-mediated signal transduction. A possible ligand for CD38 is the Ig superfamily protein CD31. In addition, activation of CD38 with a monoclonal antibody induces leukemic cell proliferation. Thus, CD38 is a cell surface protein that is important for lymphocyte migration and may be involved in the propagation of leukemic cells in AML (acute myelogenous leukemia).
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分子量
- 46 kDa
抗原
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