SRPK1 抗体 (AA 312-434)
(2 references)Quick Overview for SRPK1 抗体 (AA 312-434) (ABIN968353)
抗原
See all SRPK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 312-434
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交叉反应
- 犬, 大鼠, 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human SRPK1 aa.312-434
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亚型
- IgG1
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anti-SRSF Protein Kinase 1 (SRPK1) (AA 371-470) antibody
SRPK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) antibodySRPK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (AA 290-480) antibodySRPK1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (AA 371-470) antibodySRPK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E8 unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (AA 1-655) antibodySRPK1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (AA 371-470) antibodySRPK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G12 unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (AA 538-567), (C-Term) antibodySRPK1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB9188 unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (AA 1-30), (N-Term) antibodySRPK1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB3355 unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) antibodySRPK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-SRSF Protein Kinase 1 (SRPK1) (C-Term) antibodySRPK1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968535, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).
: "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors." in: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24569-75, (1996) (PubMed).
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: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).
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- SRPK1 (SRSF Protein Kinase 1 (SRPK1))
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别名
- SRPK1
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背景
- Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The super family of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate SR domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPL1 is specific for SR domain-containing splicing factors because it recognizes only Arg and phosphorylates only Ser. SRPK1 is expressed predominately in the pancreas, domain-containing splicing factors because it recognizes only Arg and phosphorylates only Ser. SRPK1 is expressed predominately in the pancreas, whereas SRPK2 is highly expressed in brain. SRPKs affect splice-site selection and are thought to affect alternative splicing.
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分子量
- 92 kDa
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途径
- Toll-Like Receptors Cascades
抗原
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