ITGA3 抗体 (AA 110-325)
(2 references)Quick Overview for ITGA3 抗体 (AA 110-325) (ABIN968338)
抗原
See all ITGA3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 110-325
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交叉反应
- 大鼠, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse VLA-3alpha aa. 110-325
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亚型
- IgG1
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anti-Integrin, alpha 3 (ITGA3) (AA 33-236) antibody
ITGA3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) (AA 63-248) antibodyITGA3 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5F1D4 unconjugated
anti-Integrin, alpha 3 (ITGA3) (AA 63-248) antibodyITGA3 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 7H2A11 unconjugated
anti-Integrin, alpha 3 (ITGA3) (AA 51-67), (N-Term) antibodyITGA3 适用: 人, 大鼠 WB, FACS, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) (N-Term) antibodyITGA3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) (AA 976-1025) antibodyITGA3 适用: 小鼠, Pig WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) antibodyITGA3 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) (AA 168-276) antibodyITGA3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) antibodyITGA3 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 3 (ITGA3) (AA 165-199), (N-Term) antibodyITGA3 适用: 人 WB 宿主: 兔 Polyclonal RB52792 unconjugated
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说明
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Related Products: ABIN968547, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "cDNA cloning of mouse VLA-3 alpha subunit." in: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, (1995) (PubMed).
: "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen." in: The Journal of cell biology, Vol. 115, Issue 1, pp. 257-66, (1991) (PubMed).
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: "cDNA cloning of mouse VLA-3 alpha subunit." in: Journal of cellular biochemistry, Vol. 57, Issue 2, pp. 371-7, (1995) (PubMed).
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- ITGA3 (Integrin, alpha 3 (ITGA3))
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别名
- CD49c
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背景
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Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which defines the integrin subfamilies. VLA-3 (Very Late Antigen-3), a member of the integrin superfamily, exhibits elevated expression on B lymphocytes, but is also found on monocytes, platelets, and hematopoietic progenitor cells. A heterodimer of alpha3 (CD49c) and beta1 (CD29) subunits, VLA is a receptor for laminin, fibronectin, and collagen. The alpha3 chain contains a large extracellular domain with three putative metal-binding sequences, a transmembrane domain, and a short cytoplasmic tail. Differing requirements for divalent cations and the influence of RGD peptides results in multiple ligand-binding mechanisms for VLA-3. Although its expression is restricted in normal tissues, VLA-3 is found on a variety of cultured tumor cells. In addition, levels of VLA-3 have been shown to correlate with the degree of invasiveness of malignant melanoma cells. Thus, VLA-3 mediates intercellular adhesion and cell migration in normal and, possibly, cancerous cell types.
Synonyms: Integrin alpha3, VLA-3alpha -
分子量
- 135 kDa
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途径
- CXCR4-mediated Signaling Events, Integrin Complex
抗原
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