UNC13B 抗体 (AA 621-834)
(4 references)Quick Overview for UNC13B 抗体 (AA 621-834) (ABIN968305)
抗原
See all UNC13B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 621-834
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交叉反应
- 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Rat Munc13-1 aa. 621-834
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亚型
- IgG1
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anti-Unc-13 Homolog B (UNC13B) (AA 12-215) antibody
UNC13B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) (AA 1-350) antibodyUNC13B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) (Internal Region) antibodyUNC13B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) antibodyUNC13B 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) (AA 1062-1091) antibodyUNC13B 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22476 unconjugated
anti-Unc-13 Homolog B (UNC13B) antibodyUNC13B 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) (AA 1482-1591) antibodyUNC13B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) (Internal Region) antibodyVerified UNC13B 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Unc-13 Homolog B (UNC13B) antibodyUNC13B 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release." in: Neuron, Vol. 21, Issue 1, pp. 123-36, (1998) (PubMed).
: "A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13." in: Biochemical and biophysical research communications, Vol. 248, Issue 3, pp. 846-51, (1998) (PubMed).
: "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery." in: The Journal of biological chemistry, Vol. 272, Issue 26, pp. 16081-4, (1997) (PubMed).
: "Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins." in: The Journal of biological chemistry, Vol. 270, Issue 42, pp. 25273-80, (1995) (PubMed).
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: "Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release." in: Neuron, Vol. 21, Issue 1, pp. 123-36, (1998) (PubMed).
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- UNC13B (Unc-13 Homolog B (UNC13B))
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别名
- Munc13 (Pan)
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背景
- Release of neurotransmitters at the synaptic junction is a primary mechanism of neuronal communication and is regulated by the synaptic vesicle (SV) cycle. Several components of the SV cycle were initially characterized in C. elegans. One of those, unc-13, is involved in normal presynaptic function. Mammalian homologues of unc-13 are Munc13-1, 13-2, and 13-3. These neuron-specific proteins lack N-terminal homology, but are highly conserved in their C-terminal regions. Here they contain a phorbal ester binding C1-domain and two C2-domains with homology to the PKC Ca2+/phospholipid-binding domain. The most abundant isoform, Munc 13-1, is a presynaptic receptor with high affinities for phorbol ester and DAG. In response to phorbol ester, Munc13-1 associates with the plasma membrane and acts as a stimulation dependent enhancer of neurotransmitter release. In addition, Munc13-1 interacts with components of the SV cycle (syntaxin, SNAP25, synaptobrevin, Doc2) and with a brain specific isoform of beta-spectrin, a protein that interacts with the actin cytoskeleton. Thus, it is thought that Munc13 proteins function in signaling pathways that regulate the neuronal exocytic machinery.
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分子量
- 196 kDa
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途径
- Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
抗原
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