CHRNA1 抗体 (AA 332-457)
(5 references)-
- 抗原 See all CHRNA1 抗体
- CHRNA1 (Acetylcholine Receptor Subunit alpha (CHRNA1))
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抗原表位
- AA 332-457
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适用
- 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CHRNA1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 小鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat Acetylcholine Receptor alpha aa. 332-457
- 克隆位点
- 26-Acetylcholine Receptor alpha
- 亚型
- IgG2a
- Top Product
- Discover our top product CHRNA1 Primary Antibody
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anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (AA 25-240) antibody
CHRNA1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (N-Term) antibodyCHRNA1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (AA 21-255) antibodyCHRNA1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (C-Term) antibodyCHRNA1 适用: 人, 小鼠, 犬, 豚鼠, 兔, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (AA 21-255) antibodyCHRNA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (C-Term) antibodyCHRNA1 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (AA 25-234) antibodyCHRNA1 适用: Torpedo californica ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (AA 21-230) antibodyCHRNA1 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) (N-Term) antibodyCHRNA1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Acetylcholine Receptor Subunit alpha (CHRNA1) antibodyCHRNA1 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Hypercholesterolemia promotes a CD36-dependent and endothelial nitric-oxide synthase-mediated vascular dysfunction." in: The Journal of biological chemistry, Vol. 277, Issue 26, pp. 23525-33, (2002) (PubMed).
: "Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 13, pp. 8874-9, (2002) (PubMed).
: "Involvement of human muscle acetylcholine receptor alpha-subunit gene (CHRNA) in susceptibility to myasthenia gravis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 4668-72, (1994) (PubMed).
: "Monoclonal antibodies FK1 and WF6 define two neighboring ligand binding sites on Torpedo acetylcholine receptor alpha-polypeptide." in: The Journal of biological chemistry, Vol. 269, Issue 14, pp. 10407-16, (1994) (PubMed).
: "Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells." in: The Journal of cell biology, Vol. 118, Issue 5, pp. 1201-12, (1992) (PubMed).
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: "Hypercholesterolemia promotes a CD36-dependent and endothelial nitric-oxide synthase-mediated vascular dysfunction." in: The Journal of biological chemistry, Vol. 277, Issue 26, pp. 23525-33, (2002) (PubMed).
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- 抗原
- CHRNA1 (Acetylcholine Receptor Subunit alpha (CHRNA1))
- 别名
- Acetylcholine Receptor alpha (CHRNA1 产品)
- 别名
- CHRNA1 antibody, ACHRA antibody, ACHRD antibody, CHRNA antibody, CMS2A antibody, FCCMS antibody, SCCMS antibody, NACHRA1 antibody, AI385656 antibody, AI608266 antibody, Achr-1 antibody, Acra antibody, cholinergic receptor nicotinic alpha 1 subunit antibody, cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) antibody, CHRNA1 antibody, Chrna1 antibody
- 背景
- Acetylcholine is an amine neurotransmitter at the neuromuscular junction. It is released from the presynaptic membrane of a cholinergic synapse into the synaptic cleft. It diffuses across the cleft and binds acetylcholine receptors (AChR) on the postsynaptic membrane. Receptor binding induces postsynaptic membrane depolarization and the generation of an action potential that produces effects such as muscle contraction. The AChR is a 250kDa pentameric complex of four transmembrane subunits in a stoichiometry of alpha2betagammadelta. In response to ligand binding, all subunits participate in the formation of an integral cation channel. However, the acetylcholine binding site is primarily within the alpha subunit. Myasthenia gravis (MG) is an autoimmune condition in which AchR levels are decreased. Autoantibodies bind and crosslink the AchRs leading to their internalization and degradation. This results in a decreased number of functional AChRs. Patients develop muscular weakness and some voluntary muscle fatigue. However, development of MG is also affected by genetic factors. One of the allelic forms of the AChRalpha gene appears to significantly contribute to MG susceptibility.
- 分子量
- 49 kDa
- 途径
- Skeletal Muscle Fiber Development
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