Metabotropic Glutamate Receptor 1 抗体 (AA 1042-1160)
(5 references)Quick Overview for Metabotropic Glutamate Receptor 1 抗体 (AA 1042-1160) (ABIN968280)
抗原
See all Metabotropic Glutamate Receptor 1 (GRM1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1042-1160
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交叉反应
- 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Rat mGluR1 aa. 1042-1160
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亚型
- IgG1
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anti-Glutamate Receptor, Metabotropic 1 (GRM1) (AA 165-592) antibody
GRM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (AA 501-516), (Extracellular) antibodyGRM1 适用: 大鼠 WB, IP, IF, IC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) antibodyGRM1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (AA 387-486) antibodyGRM1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5E12D8 unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (AA 880-1017) antibodyGRM1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (C-Term) antibodyGRM1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (N-Term) antibodyGRM1 适用: 人, Cow, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (AA 387-486) antibodyGRM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F7 unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (Internal Region) antibodyGRM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 1 (GRM1) (AA 387-486) antibodyGRM1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, (1999) (PubMed).
: "A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 425-32, (1998) (PubMed).
: "The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins." in: The Journal of biological chemistry, Vol. 271, Issue 4, pp. 2199-205, (1996) (PubMed).
: "A family of metabotropic glutamate receptors." in: Neuron, Vol. 8, Issue 1, pp. 169-79, (1992) (PubMed).
: "Sequence and expression of a metabotropic glutamate receptor." in: Nature, Vol. 349, Issue 6312, pp. 760-5, (1991) (PubMed).
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: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, (1999) (PubMed).
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- Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))
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别名
- mGluR1
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背景
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Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca[2+] sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca2+ mobilization necessary for many signal transduction events.
Synonyms: Metabotropic Glutamate Receptor-1 -
分子量
- 133 kDa
抗原
-
