DIAPH1 抗体 (AA 41-153)
(3 references)-
- 抗原 See all DIAPH1 抗体
- DIAPH1 (Diaphanous Homolog 1 (DIAPH1))
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抗原表位
- AA 41-153
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This DIAPH1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 交叉反应
- 大鼠, 人, 犬
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse p140mDia aa. 41-153
- 克隆位点
- 51-mDia1
- 亚型
- IgG1
- Top Product
- Discover our top product DIAPH1 Primary Antibody
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anti-Diaphanous Homolog 1 (DIAPH1) (C-Term) antibody
DIAPH1 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) antibodyDIAPH1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (N-Term) antibodyDIAPH1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 1-404) antibodyDIAPH1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) antibodyDIAPH1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 389-583) antibodyDIAPH1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 18-52), (N-Term) antibodyDIAPH1 适用: 人 WB 宿主: 兔 Polyclonal RB30760 unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 921-1024) antibodyDIAPH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 1-404) antibodyDIAPH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Diaphanous Homolog 1 (DIAPH1) (AA 1-404) antibodyDIAPH1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition." in: Current biology : CB, Vol. 13, Issue 15, pp. 1335-40, (2003) (PubMed).
: "The architecture of hearing." in: Science (New York, N.Y.), Vol. 278, Issue 5341, pp. 1223-4, (1997) (PubMed).
: "p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin." in: The EMBO journal, Vol. 16, Issue 11, pp. 3044-56, (1997) (PubMed).
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: "The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition." in: Current biology : CB, Vol. 13, Issue 15, pp. 1335-40, (2003) (PubMed).
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- 抗原
- DIAPH1 (Diaphanous Homolog 1 (DIAPH1))
- 别名
- p140mDia (DIAPH1 产品)
- 别名
- DIAPH1 antibody, dia1 antibody, drf1 antibody, dfna1 antibody, diap1 antibody, lfhl1 antibody, DIAPH2 antibody, Diap1 antibody, D18Wsu154e antibody, Dia1 antibody, Diaph1 antibody, Drf1 antibody, mKIAA4062 antibody, p140mDia antibody, DFNA1 antibody, DIA1 antibody, DRF1 antibody, LFHL1 antibody, hDIA1 antibody, diaphanous related formin 1 antibody, diaphanous related formin 2 antibody, diaphanous-related formin 1 antibody, protein diaphanous homolog 1 antibody, DIAPH1 antibody, diaph1 antibody, DIAPH2 antibody, Diaph1 antibody, LOC100457442 antibody
- 背景
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GTPases like Ras, Rho, cdc42Hs, and Rac modulate a multitude of cellular functions like cytoskeletal architecture, growth, motility, and gene expression. The activity of the GTP-binding proteins is regulated by factors that accelerate GTP-binding (GAPs) and proteins that enhance the rate of GTP hydrolysis. mDia1, also known as p140mDia and Drf1, is the mammalian homologue of Drosophila's diaphanous, a protein essential for cytokinesis. The 1255 amino acid mDia1 is widely expressed, with a Rho binding domain at the NH2-terminal region, a central polyproline region, and an FH2 domain. This protein also shares homology with the yeast Bn1p essential for budding and the mouse formin necessary for proper limb development. mDia1 binds to GTP-Rho and to the actin-binding protein profilin-all three proteins are co-localized at the lamellipodia in cultured cells. The overexpression of mDia1 promoted the formation of actin filaments, implicating this protein in cell motility events regulated by Rho. mDia1 was also found consistently mutated in familial deafness.
Synonyms: p140mDia, Drf1 - 分子量
- 140 kDa
- 途径
- Sensory Perception of Sound
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