ITGAL 抗体 (AA 64-199)
(4 references)-
- 抗原 See all ITGAL 抗体
- ITGAL (Integrin alpha-L (ITGAL))
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抗原表位
- AA 64-199
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ITGAL antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human LFA-1alpha aa. 64-199
- 克隆位点
- 27-CD11a
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product ITGAL Primary Antibody
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anti-Integrin alpha-L (ITGAL) (AA 26-306) antibody
ITGAL 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-L (ITGAL) (AA 26-194) antibodyITGAL 适用: 人 FACS, WB, IHC, ELISA, ICC, Neut 宿主: 小鼠 Monoclonal 5G7C5 unconjugated
anti-Integrin alpha-L (ITGAL) antibodyITGAL 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-L (ITGAL) antibodyITGAL 适用: 人 FACS, IP, IHC 宿主: 小鼠 Monoclonal 38 unconjugated
anti-Integrin alpha-L (ITGAL) (AA 201-500) antibodyITGAL 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-L (ITGAL) antibodyITGAL 适用: 小鼠 FACS, IP, IHC (fro) 宿主: 大鼠 Monoclonal M17-4 unconjugated
anti-Integrin alpha-L (ITGAL) antibodyITGAL 适用: 小鼠 FACS, IP, Func, IHC (fro) 宿主: 大鼠 Monoclonal M17-4 unconjugated
anti-Integrin alpha-L (ITGAL) antibodyITGAL 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal MEM-25 unconjugated
anti-Integrin alpha-L (ITGAL) antibodyITGAL 适用: 人 FACS, IP, Func 宿主: 小鼠 Monoclonal MEM-25 unconjugated
anti-Integrin alpha-L (ITGAL) antibody (Biotin)ITGAL 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal MEM-25 Biotin
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Repression of IRF-4 target genes in human T cell leukemia virus-1 infection." in: Oncogene, Vol. 21, Issue 44, pp. 6751-65, (2002) (PubMed).
: "Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1." in: Molecular biology of the cell, Vol. 8, Issue 2, pp. 341-51, (1997) (PubMed).
: "Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter." in: The Journal of biological chemistry, Vol. 268, Issue 26, pp. 19305-11, (1993) (PubMed).
: "Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily." in: The Journal of cell biology, Vol. 108, Issue 2, pp. 703-12, (1989) (PubMed).
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: "Repression of IRF-4 target genes in human T cell leukemia virus-1 infection." in: Oncogene, Vol. 21, Issue 44, pp. 6751-65, (2002) (PubMed).
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- 抗原
- ITGAL (Integrin alpha-L (ITGAL))
- 别名
- CD11a (ITGAL 产品)
- 别名
- CD11A antibody, LFA-1 antibody, LFA1A antibody, (p180) antibody, Cd11a antibody, LFA-1A antibody, Ly-15 antibody, Ly-21 antibody, CD11a antibody, ITGAL antibody, integrin subunit alpha L antibody, integrin alpha L antibody, ITGAL antibody, Itgal antibody
- 背景
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CD11a, also known as integrin alphaL or LFA-1 (lymphocyte function-associated antigen-1), is a member of the beta2 family of integrins that includes Mac-1 and p150,95. It is composed of two noncovalently linked alpha and beta chains which are associated with the actin cytoskeleton. CD11a (integrin alphaL) has been reported to be expressed on the surface of T cells, neutrophils, and macrophages. It is involved in cell-cell adhesion and it also conveys signals from the plasma membrane to the cytoplasm. Activation of the TCR/CD3 complex on T cells transmits intracellular signals that activate integrin alphaL (inside-out” signaling). This results in the conformational change of integrin alphaL, which increases its affinity for its ligand ICAM-1,-2, and -3. Furthermore, this signaling releases integrin alphaL from the actin cytoskeleton, resulting in clustering of this surface molecule. The high affinity conformation and the clustering of integrin alphaL increases the adhesion between it and ICAM. This adhesion is essential for leukocyte activation and results in outside-in” signaling which induces the polymerization of actin, thereby stabilizing the integrin alphaL-ICAM interaction. This interaction is necessary for CTL and NK mediated killing, T and B cell responses, ADCC, and immune cell extravasation. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin alphaL, LFA-1alpha - 分子量
- 180 kDa
- 途径
- Activated T Cell Proliferation, Integrin Complex
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