JNK/SAPK1 (Pan) (AA 264-415) 抗体
There are 3+ publications for this product available. The 小鼠 单克隆 anti-JNK/SAPK1 (Pan) antibody is suitable to detect JNK/SAPK1 (Pan) in samples from 小鸡, 犬, Frog, 人, 小鼠 和 大鼠. It has been validated for IF, IP, IHC 和 WB.
(3 references)
产品编号 ABIN968075
发货至:
中国
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Quick Overview for JNK/SAPK1 (Pan) (AA 264-415) 抗体 (ABIN968075)
抗原
JNK/SAPK1 (Pan)
适用
小鸡, 犬, Frog, 人, 小鼠, 大鼠
宿主
小鼠
克隆类型
单克隆
应用范围
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
克隆位点
37-pan
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抗原表位
- AA 264-415
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交叉反应
- 大鼠, 犬, 小鼠, 小鸡, Frog
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human MAPKp49 aa. 264-415
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亚型
- IgG1
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说明
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Related Products: ABIN968539, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "The hem of the garment." in: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, (2001) (PubMed).
: "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system." in: Neuron, Vol. 14, Issue 1, pp. 67-78, (1995) (PubMed).
: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." in: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, (1988) (PubMed).
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- JNK/SAPK1 (Pan)
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背景
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The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, such as endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. The ultimate cellular response to environmental stress is cell death or apoptosis. This pathway is regulated by Rac1 and Cdc42 which link Jun Kinases (JNKs), such as p38. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK contains homology with the MAP/ERK family of kinases, and contains an N-terminal ATP-binding site and two autophosphorylation TXY sites. JNKK1/MEKK4/SEK1 is a dual-specificity kinase activated by conditions of cellular stress, such as heat shock and hyperosmolarity. JNKK1 phosphorylates JNK and p38 but not the ERK MAP kinases. Active JNK and p38 phosphorylate multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
Synonyms: p49 MAPK -
分子量
- 49 kDa
抗原
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