Gephyrin 抗体 (AA 569-726)
(4 references)Quick Overview for Gephyrin 抗体 (AA 569-726) (ABIN968051)
抗原
See all Gephyrin (GPHN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 569-726
-
交叉反应
- 小鸡, 人, 小鼠
-
产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
免疫原
- Rat Gephyrin aa. 569-726
-
亚型
- IgG1
-
-
anti-Gephyrin (GPHN) antibody
GPHN 适用: 人, 猴 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Gephyrin (GPHN) antibodyGPHN 适用: 人, 大鼠, 猴 WB, FACS 宿主: 小鼠 Monoclonal 3A6 unconjugated
anti-Gephyrin (GPHN) (AA 360-460) antibodyGPHN 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) antibodyGPHN 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 677-769) antibodyGPHN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 520-769) antibodyGPHN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 437-466) antibodyGPHN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24625 unconjugated
anti-Gephyrin (GPHN) (AA 444-474), (Middle Region) antibodyGPHN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 1-769) antibodyGPHN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Gephyrin (GPHN) (AA 396-445) antibodyGPHN 适用: 人, 小鼠, 大鼠, 斑马鱼, 小鸡, 猴, Cow, 犬, 豚鼠, 马, 兔, 非洲爪蟾, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
-
-
说明
-
Related Products: ABIN968546, ABIN967389
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 250 μg/mL
-
缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store undiluted at -20° C.
-
-
-
: "The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 15, pp. 8594-9, (2000) (PubMed).
: "Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity." in: Science (New York, N.Y.), Vol. 282, Issue 5392, pp. 1321-4, (1998) (PubMed).
: "Identification of a gephyrin binding motif on the glycine receptor beta subunit." in: Neuron, Vol. 15, Issue 3, pp. 563-72, (1995) (PubMed).
: "Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein." in: Neuron, Vol. 8, Issue 6, pp. 1161-70, (1992) (PubMed).
-
: "The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 15, pp. 8594-9, (2000) (PubMed).
-
- Gephyrin (GPHN)
-
别名
- Gephyrin
-
背景
- The sub-membraneous region of the postsynaptic neuron is an intricate network of cytoskeletal elements generally known as the postsynaptic density. It is thought that this elaborate cytoskeletal region is critical for receptor targeting, clustering, and efficient signal input. Gephyrin, a 93 kDa protein, was identified as a result of its ability to bind to polymerized tubulin (microtubules). Although expressed in all tissues, gephyrin mRNA is found most abundantly in brain. Alternative splicing produces at least five different mRNAs. Gephyrin colocalizes and interacts with the glycine receptor at the postsynaptic density. It is possible that Gephyrin acts as an anchor between the glycine receptor and microtubules. This antibody is routinely tested by western blot analysis.
-
分子量
- 93 kDa
-
途径
- Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
-
