CaM Kinase Kinase (AA 341-504) 抗体
Cited in 5+ publications.
The 小鼠 单克隆 anti-CaM Kinase Kinase antibody (Clone 6-CaM Kinase Kinase) (ABIN968028) specifically detects CaM Kinase Kinase in IF, IP, IHC 和 WB.
The antibody is reactive with 犬, 人 和 大鼠 samples.
1 image
(5 references)
产品编号 ABIN968028
发货至:
中国
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中国
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Quick Overview for CaM Kinase Kinase (AA 341-504) 抗体 (ABIN968028)
抗原
CaM Kinase Kinase
适用
犬, 人, 大鼠
宿主
小鼠
克隆类型
单克隆
应用范围
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
克隆位点
6-CaM Kinase Kinase
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抗原表位
- AA 341-504
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交叉反应
- 人, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Rat CaM Kinase Kinase aa. 341-504
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亚型
- IgG2a
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Neuronal survival induced by neurotrophins requires calmodulin." in: The Journal of cell biology, Vol. 154, Issue 3, pp. 585-97, (2001) (PubMed).
: "CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 811-24, (2000) (PubMed).
: "Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix." in: The Journal of biological chemistry, Vol. 275, Issue 11, pp. 7994-9, (2000) (PubMed).
: "Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence." in: The Journal of biological chemistry, Vol. 271, Issue 18, pp. 10806-10, (1996) (PubMed).
: "Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase." in: The Journal of biological chemistry, Vol. 270, Issue 33, pp. 19320-4, (1995) (PubMed).
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: "Neuronal survival induced by neurotrophins requires calmodulin." in: The Journal of cell biology, Vol. 154, Issue 3, pp. 585-97, (2001) (PubMed).
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- CaM Kinase Kinase
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背景
- Ca2+/Calmodulin (CaM)-dependent kinases are multifunctional kinases involved in a myriad of cellular functions such as neurotransmitter synthesis, long-term potentiation, and formation of spatial learning. A 68kDa CaM Kinase Kinase with homology to the Ca2+/CaM-dependent kinases, phosphorylates and activates Ca2+/CaM-dependent protein kinases I and IV, but not type II. This phosphorylation occurs on Ser/Thr residues and is Ca2+ and CaM dependent. CaM Kinase Kinase is abundant in brain tissue, and is thought to be an upstream regulator in the Ca2+/CaM-dependent neural processes. This antibody is routinely tested by western blot analysis.
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分子量
- 68 kDa
抗原
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