eIF-4gamma (AA 1217-1386) 抗体
This 小鼠 单克隆 antibody specifically detects eIF-4gamma in IF, IP, IHC 和 WB. It exhibits reactivity toward 犬 和 人. It has been mentioned in 3+ publications
(3 references)
产品编号 ABIN968023
发货至:
中国
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Quick Overview for eIF-4gamma (AA 1217-1386) 抗体 (ABIN968023)
抗原
eIF-4gamma
适用
犬, 人
宿主
小鼠
克隆类型
单克隆
应用范围
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
克隆位点
40-eIF
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抗原表位
- AA 1217-1386
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交叉反应
- 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human eIF-4gamma aa. 1217-1386
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亚型
- IgG1
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说明
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Related Products: ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules." in: Molecular biology of the cell, Vol. 13, Issue 1, pp. 195-210, (2002) (PubMed).
: "Internal initiation of translation directed by the 5'-untranslated region of the mRNA for eIF4G, a factor involved in the picornavirus-induced switch from cap-dependent to internal initiation." in: The Journal of biological chemistry, Vol. 271, Issue 2, pp. 623-6, (1996) (PubMed).
: "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma." in: The Journal of biological chemistry, Vol. 267, Issue 32, pp. 23226-31, (1992) (PubMed).
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- eIF-4gamma
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背景
- EIF-4 proteins are required for mRNA recognition and acceleration of translation during protein synthesis. This group of proteins consists of the RNA helicase, eIF-4A, the RNA-binding protein, eIF-4B, and the cap binding proteins, eIF-4E and eIF-4gamma. eIF-4gamma, also referred to as p220, is a 1396 amino acid polypeptide that migrates as a 220kDa. eIF-4gamma has several potential glycosylation and phosphorylation sites that could account for its anomalous electrophoretic mobility. In addition, eIF-4gamma is rapidly degraded in picornavirus-infected cells due to its content of multiple PEST sequences.
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分子量
- 220 kDa
抗原
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