ITGB1 抗体 (AA 76-256)
(5 references)Quick Overview for ITGB1 抗体 (AA 76-256) (ABIN967992)
抗原
See all ITGB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 76-256
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交叉反应
- 犬, 大鼠, 小鼠, 小鸡
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human CD29 aa. 76-256
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亚型
- IgG1
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anti-Integrin beta 1 (ITGB1) (AA 25-100) antibody
ITGB1 适用: 人, 小鼠, 大鼠, 绵羊, 兔 WB, FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 1 (ITGB1) antibodyITGB1 适用: 人, 猴 WB, FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Integrin beta 1 (ITGB1) (AA 140-383) antibodyITGB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 1 (ITGB1) antibodyITGB1 适用: 人, Pig, 犬 WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-101A unconjugated
anti-Integrin beta 1 (ITGB1) antibody (PE)ITGB1 适用: 人, Pig, 犬 FACS 宿主: 小鼠 Monoclonal MEM-101A PE
anti-Integrin beta 1 (ITGB1) (AA 297-380) antibodyITGB1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 1 (ITGB1) antibodyITGB1 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 兔 Monoclonal 32A10 unconjugated Recombinant Antibody
anti-Integrin beta 1 (ITGB1) (AA 454-714) antibodyITGB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 1 (ITGB1) (AA 140-383) antibodyITGB1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Integrin beta 1 (ITGB1) (Subunit 1 beta) antibody (FITC)ITGB1 适用: 人 FACS, IHC, IHC (p) 宿主: 小鼠 Monoclonal FITC
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说明
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Related Products: ABIN967389, ABIN968533
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "PKC epsilon controls the traffic of beta1 integrins in motile cells." in: The EMBO journal, Vol. 21, Issue 14, pp. 3608-19, (2002) (PubMed).
: "Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5441-7, (2002) (PubMed).
: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." in: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, (1999) (PubMed).
: "Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis." in: Blood, Vol. 92, Issue 9, pp. 3268-76, (1998) (PubMed).
: "Human beta 1-integrin gene expression is regulated by two promoter regions." in: The Journal of biological chemistry, Vol. 268, Issue 7, pp. 5148-55, (1993) (PubMed).
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: "PKC epsilon controls the traffic of beta1 integrins in motile cells." in: The EMBO journal, Vol. 21, Issue 14, pp. 3608-19, (2002) (PubMed).
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- ITGB1 (Integrin beta 1 (ITGB1))
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别名
- CD29
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背景
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Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of alpha and beta subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 alpha and 9 beta subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The beta1 subgroup of this receptor family comprises at least six different dimer combinations. Among these combinations, alpha2beta1 is associated with type I collagen and laminin binding and regulation, alpha3beta1 is a receptor for laminin and epiligrin, and alpha5beta1 is a fibronectin receptor. beta1 integrins play an important role in several aspects of epidermal differentiation and morphogenesis. Expression of the beta1 subunit is regulated by growth factors such as TGF-beta1. Integrin activation, which enhances binding of T cells to endothelium, is regulated in part by phosphatidylinositol 3-kinase. Focal adhesion kinase (FAK) and paxillin have been reported to independently bind the C-terminal, cytoplasmic domain of the beta1 subunit. FAK is reported to be enzymatically activated upon engagement of integrins with their ligands and paxillin is phosphorylated on tyrosine upon activation of FAK.
Synonyms: Integrin beta1, platelet GPIIa, VLA beta-chain -
分子量
- 130 kDa
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途径
- Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome
抗原
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