Syntaxin 4 抗体 (AA 1-280)
(4 references)Quick Overview for Syntaxin 4 抗体 (AA 1-280) (ABIN967968)
抗原
See all Syntaxin 4 (STX4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 1-280
-
产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
免疫原
- Human Syntaxin 4 aa. 1-280
-
亚型
- IgG1
-
-
anti-Syntaxin 4 (STX4) (AA 19-119) antibody
STX4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6A1 unconjugated
anti-Syntaxin 4 (STX4) (AA 1-297) antibodySTX4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) antibodySTX4 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Syntaxin 4 (STX4) (AA 1-297) antibodySTX4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (AA 101-150) antibodySTX4 适用: 人, 大鼠, 小鼠, Cow, Pig, 兔, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (C-Term) antibodySTX4 适用: 人, Cow, Pig, 兔, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (AA 1-273), (Cytoplasmic Domain) antibodySTX4 适用: 人, 大鼠, 小鼠, Hamster WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) (AA 1-273), (Cytoplasmic Domain) antibodySTX4 适用: 大鼠, 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal 139-2 unconjugated
anti-Syntaxin 4 (STX4) (AA 1-275) antibodySTX4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Syntaxin 4 (STX4) antibodySTX4 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 4E1 unconjugated Recombinant Antibody
-
-
说明
-
Related Products: ABIN968536, ABIN967389
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 250 μg/mL
-
缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store undiluted at -20°C.
-
-
-
: "Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery." in: Molecular biology of the cell, Vol. 11, Issue 10, pp. 3485-94, (2000) (PubMed).
: "SNAREs in mammalian sperm: possible implications for fertilization." in: Developmental biology, Vol. 223, Issue 1, pp. 54-69, (2000) (PubMed).
: "Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation." in: Neuron, Vol. 14, Issue 5, pp. 991-8, (1995) (PubMed).
: "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones." in: Science (New York, N.Y.), Vol. 257, Issue 5067, pp. 255-9, (1992) (PubMed).
-
: "Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery." in: Molecular biology of the cell, Vol. 11, Issue 10, pp. 3485-94, (2000) (PubMed).
-
- Syntaxin 4 (STX4)
-
别名
- Syntaxin 4
-
背景
-
Signal transmission between neurons is regulated by the release of neurotransmitters at the synapse. This process is controlled by a complex pathway of membrane trafficking in the presynaptic nerve terminal, which leads to membrane fusion and subsequent neurotransmitter secretion. Syntaxin is involved in three important protein complexes that modulate this process: syntaxin and n-sec1, syntaxin, VAMP and SNAP-25, and syntaxin, VAMP, SNAP-25, alphaSNAP, and NSF (20S complex). A model has been proposed to explain docking, activation, and fusion of synaptic vesicles with donor membranes. This model suggests that VAMP/synaptobrevin and synaptotagmin (vSNARE) on the synaptic vesicle, and SNAP-25 and syntaxin (tSNAREs) on the plasma membrane, interact to form a 7S complex. It appears that syntaxin associates with -sec1 prior to and/or during the formation of the 7S complex. Two additional soluble proteins, alphaSNAP and NSF, associate with this complex as synaptotagmin releases from the complex. The resulting 20S complex contains syntaxin, SNAP-25, VAMP, alphaSNAP, and NSF. A large region including the N-terminus is involved in binding n-sec1 while both VAMP and SNAP-25 bind within residues 199-288 of syntaxin.
Synonyms: STX4 -
分子量
- 32 kDa
-
途径
- Synaptic Vesicle Exocytosis
抗原
-
