Synaptotagmin 抗体 (AA 72-223)
(5 references)Quick Overview for Synaptotagmin 抗体 (AA 72-223) (ABIN967965)
抗原
See all Synaptotagmin (SYT) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 72-223
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交叉反应
- 人
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- Purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Rat Synaptotagmin
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亚型
- IgG1
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anti-Synaptotagmin (SYT) (AA 165-260) antibody
SYT 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (pSer309) antibodySYT 适用: 大鼠, 小鼠, 人 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (pThr202) antibodySYT 适用: 大鼠, 小鼠, 人 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (Ser1148) antibodySYT 适用: 大鼠, 小鼠, 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (Ser113) antibodySYT 适用: 大鼠, 小鼠, 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (Center) antibodySYT 适用: 大鼠, 小鼠, 人, Cow, 小鸡, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (AA 176-225), (pThr202) antibodySYT 适用: 大鼠, 小鼠, 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Synaptotagmin (SYT) (AA 276-325), (pSer309) antibodySYT 适用: 大鼠, 小鼠, 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 µg/ml
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缓冲液
- Aqueous buffered solution containing BSA, glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, (2002) (PubMed).
: "SNAREs in mammalian sperm: possible implications for fertilization." in: Developmental biology, Vol. 223, Issue 1, pp. 54-69, (2000) (PubMed).
: "High-efficiency Semliki Forest virus-mediated transduction in bovine adrenal chromaffin cells." in: The Biochemical journal, Vol. 342 Pt 3, pp. 497-501, (1999) (PubMed).
: "Membrane trafficking in the presynaptic nerve terminal." in: Neuron, Vol. 14, Issue 5, pp. 893-7, (1995) (PubMed).
: "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans." in: The Journal of biological chemistry, Vol. 266, Issue 1, pp. 615-22, (1991) (PubMed).
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: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, (2002) (PubMed).
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- Synaptotagmin (SYT)
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别名
- Synaptotagmin
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背景
- Synaptotagmin (p65) is an abundant synaptic vesicle protein that contains a single transmembrane region and two copies of an internal repeat that is homologous to the regulatory region of Protein Kinase C. It appears that synaptotagmin has a regulatory role in the synaptic vesicle pathway, particularly in vesicle docking and/or fusion with the plasmalemma. A model has been proposed to explain docking, activation, and fusion of synaptic vesicles with donor membranes. This model suggests that VAMP/synaptobrevin and synaptotagmin (vSNARE) on the synaptic vesicle, and SNAP-25 and syntaxin (tSNAREs) on the plasma membrane, interact to form a 7S complex. Two additional soluble proteins, alphaSNAP and NSF, are later added to the 7S complex, accompanied by the loss of synaptotagmin. The resulting 20S complex contains syntaxin, SNAP-25, VAMP, alphaSNAP, and NSF. Genetic studies in several species demonstrate that mutation or deletion of synaptotagmin results in a large decrease in Ca2+ triggered transmitter release. Mammalian synapses that lack synaptotagmin show a selective decrease in a fast component of release, suggesting that synaptotagmin is the Ca2+ sensor triggering exocytosis.
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分子量
- 65 kDa
抗原
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