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Cyclin D3 抗体 (AA 127-292)

CCND3 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IP, IF 宿主: 小鼠 Monoclonal 1-Cyclin D3 unconjugated
产品编号 ABIN967879
发货至: 中国
  • 抗原 See all Cyclin D3 (CCND3) 抗体
    Cyclin D3 (CCND3)
    抗原表位
    • 33
    • 16
    • 11
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 127-292
    适用
    • 113
    • 49
    • 38
    • 16
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 99
    • 16
    小鼠
    克隆类型
    • 91
    • 24
    单克隆
    标记
    • 52
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cyclin D3 antibody is un-conjugated
    应用范围
    • 85
    • 34
    • 33
    • 27
    • 26
    • 20
    • 15
    • 15
    • 10
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    交叉反应
    小鼠, 大鼠, 犬
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Cyclin D3 aa. 127-292
    克隆位点
    1-Cyclin D3
    亚型
    IgG2b
    Top Product
    Discover our top product CCND3 Primary Antibody
  • 说明

    Related Products: ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Haller, Wu, Derow, Schmitt, Jeang, Grassmann: "Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3327-38, (2002) (PubMed).

    Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

    Bagui, Jackson, Agrawal, Pledger: "Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1)." in: Molecular and cellular biology, Vol. 20, Issue 23, pp. 8748-57, (2000) (PubMed).

    Motokura, Keyomarsi, Kronenberg, Arnold: "Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene." in: The Journal of biological chemistry, Vol. 267, Issue 28, pp. 20412-5, (1992) (PubMed).

    Xiong, Menninger, Beach, Ward: "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." in: Genomics, Vol. 13, Issue 3, pp. 575-84, (1992) (PubMed).

  • 抗原
    Cyclin D3 (CCND3)
    别名
    Cyclin D3 (CCND3 产品)
    别名
    zgc:103502 antibody, CCND3 antibody, 9230106B05Rik antibody, AA682053 antibody, AL024085 antibody, AW146355 antibody, C78795 antibody, cyclin D3 antibody, ccnd3 antibody, CCND3 antibody, Ccnd3 antibody
    背景
    Several classes of cyclins (A-E) have been described. These proteins act as regulatory subunits for cyclin-dependent kinases (cdks). The synthesis and degradation of cyclins is tightly controlled in a cell cycle specific manner. There are at least 3 different D-type cyclins whose relative levels vary among cell types. Cyclin D3 is known to associate with Cdk5 and weakly with Cdk2. Cdk4 is preferentially bound by Cyclin D1. However, in T cells which do not express Cyclin D1, Cdk4 associates with Cyclins D2 and D3. While bound to cdks, the D-type cyclins also associate with the polymerase-delta subunit, PCNA. Cyclin D3 has also been shown to bind pRb in vitro. This suggests that pRb may be an in vivo substrate of D-type cyclins. This antibody is routinely tested by western blot analysis.
    分子量
    33 kDa
    途径
    Cell Division Cycle, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
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