Desmoglein (AA 705-1029) 抗体
This 小鼠 单克隆 antibody specifically detects Desmoglein in WB. It exhibits reactivity toward Blow Fly, 小鸡, 犬, 人, 小鼠 和 大鼠. It has been mentioned in 5+ publications
1 image
(5 references)
产品编号 ABIN967873
发货至:
中国
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Quick Overview for Desmoglein (AA 705-1029) 抗体 (ABIN967873)
抗原
Desmoglein
适用
Blow Fly, 小鸡, 犬, 人, 小鼠, 大鼠
宿主
小鼠
克隆类型
单克隆
应用范围
Western Blotting (WB)
克隆位点
62-Desmoglein
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抗原表位
- AA 705-1029
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交叉反应
- 小鼠, 大鼠, 犬, 小鸡, Fruit Fly (Drosophila melanogaster)
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Desmoglein aa. 705-1029
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亚型
- IgG2b
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说明
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Related Products: ABIN968535, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Differential regulation of endogenous cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and activation of beta -catenin signaling." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20707-16, (2000) (PubMed).
: "A novel component of epidermal cell-matrix and cell-cell contacts: transmembrane protein type XIII collagen." in: The Journal of investigative dermatology, Vol. 113, Issue 4, pp. 635-42, (1999) (PubMed).
: "Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat." in: Journal of andrology, Vol. 20, Issue 2, pp. 198-213, (1999) (PubMed).
: "Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin." in: The Journal of biological chemistry, Vol. 269, Issue 19, pp. 14075-80, (1994) (PubMed).
: "Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 11, pp. 4796-800, (1991) (PubMed).
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- Desmoglein
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背景
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Desmoglein (Dsg1) is a transmembrane glycoprotein found in desmosome junctions. Desmosomes and adherens junctions are plasma membrane specializations involved in cell-cell adhesion. They serve as membrane anchorage domains for intermediate filaments and microfilaments, respectively. Actin microfilaments anchor at adherens junctions, which occur in many sizes, shapes, and positions. These junctions generally contain E- or N-Cadherin whose cytoplasmic region is associated with cytoplasmic proteins such as alpha- and beta- catenin, vinculin, alpha-actinin, and radixin. Intermediate filaments (IFs) are anchored at desmosomes which contain desmosome-specific cadherin family members, known as desmocollin (Dsc) and desmoglein. These proteins associate with cytoplasmic proteins such as desmoplakin and plakoglobin (gamma-Catenin). Plakoglobin is the only junctional protein found at both desmosomes and adherens junctions and, therefore, plays a crucial role in cell adhesion.
Synonyms: Dsg1 -
分子量
- 165 kDa
抗原
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