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Annexin a1 抗体 (AA 1-346)

Cited in 4+ publications. The 小鼠 单克隆 anti-Annexin a1 antibody (Clone 29-Annexin I) (ABIN967719) specifically detects Annexin a1 in WB, IHC, IP 和 IF. The antibody is reactive with 人 和 犬 samples.
产品编号 ABIN967719
发货至: 中国
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Quick Overview for Annexin a1 抗体 (AA 1-346) (ABIN967719)

抗原

See all Annexin a1 (ANXA1) 抗体
Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

适用

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  • 34
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  • 1
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人, 犬

宿主

  • 190
  • 138
  • 11
  • 1
小鼠

克隆类型

  • 180
  • 159
单克隆

标记

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This Annexin a1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

克隆位点

29-Annexin I
  • 抗原表位

    • 36
    • 35
    • 21
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    • 11
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    AA 1-346

    交叉反应

    人, 犬

    产品特性

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    纯化方法

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    免疫原

    Cow Annexin I aa. 1-346

    亚型

    IgG1
  • 说明

    Related Products: ABIN968536, ABIN967389

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    250 μg/mL

    缓冲液

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store undiluted at -20° C.
  • Hansen, Ehrlich, Nelson: "Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45371-6, (2002) (PubMed).

    Graham, Gerke, Burgoyne: "Modification of annexin II expression in PC12 cell lines does not affect Ca(2+)-dependent exocytosis." in: Molecular biology of the cell, Vol. 8, Issue 3, pp. 431-42, (1997) (PubMed).

    Chasserot-Golaz, Vitale, Sagot, Delouche, Dirrig, Pradel, Henry, Aunis, Bader: "Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells." in: The Journal of cell biology, Vol. 133, Issue 6, pp. 1217-36, (1996) (PubMed).

    Regnouf, Sagot, Delouche, Devilliers, Cartaud, Henry, Pradel: ""In vitro" phosphorylation of annexin 2 heterotetramer by protein kinase C. Comparative properties of the unphosphorylated and phosphorylated annexin 2 on the aggregation and fusion of chromaffin granule membranes." in: The Journal of biological chemistry, Vol. 270, Issue 45, pp. 27143-50, (1995) (PubMed).

  • 抗原

    Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

    别名

    Annexin I

    背景

    Annexin I, also known as lipocortin-1 or calpactin II, is part of a calcium-dependent phospholipid-binding protein family. Members share a common core domain, but each has a unique N-terminal tail that imparts its functional specificity. It is believed that phosphorlyation of this region in annexin I regulates its functions. Annexin I has been implicated in regulating phospholipid vesicle aggregation, mediating inflammatory response, and inhibiting the activity of phospholipase A2. Additionally, it has been found that the 10 kDa protein S100C influences annexin I's activity by binding to the N-terminal 13 residues of annexin in a manner similar to that of the annexin II/p11 complex.
    Synonyms: Lipocortin-1, Calpactin II

    分子量

    38 kDa

    途径

    Hormone Transport
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