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Myogenin 抗体 (AA 30-224)

MYOG 适用: 人, 小鼠, 大鼠, Cat WB, IF, IHC (f), IHC (fro), BI, ICS 宿主: 小鼠 Monoclonal F5D unconjugated
产品编号 ABIN967512
发货至: 中国
  • 抗原 See all Myogenin (MYOG) 抗体
    Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
    抗原表位
    • 32
    • 15
    • 15
    • 12
    • 12
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 30-224
    适用
    • 112
    • 82
    • 57
    • 40
    • 28
    • 14
    • 13
    • 12
    人, 小鼠, 大鼠, Cat
    宿主
    • 72
    • 60
    • 1
    小鼠
    克隆类型
    • 71
    • 62
    单克隆
    标记
    • 65
    • 10
    • 10
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Myogenin antibody is un-conjugated
    应用范围
    • 102
    • 75
    • 35
    • 31
    • 30
    • 21
    • 15
    • 13
    • 11
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), BioImaging (BI), Intracellular Staining (ICS)
    品牌
    BD Pharmingen™
    交叉反应
    人, 小鼠, 猫
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Rat Myogenin aa. 30-224 Recombinant Protein
    克隆位点
    F5D
    亚型
    IgG1
    Top Product
    Discover our top product MYOG Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Ryan, Liu, Chu, Wang, Blais, Skerjanc: "Retinoic acid enhances skeletal myogenesis in human embryonic stem cells by expanding the premyogenic progenitor population." in: Stem cell reviews, Vol. 8, Issue 2, pp. 482-93, (2012) (PubMed).

    Meadows, Cho, Flynn, Klein: "Myogenin regulates a distinct genetic program in adult muscle stem cells." in: Developmental biology, Vol. 322, Issue 2, pp. 406-14, (2009) (PubMed).

    Gang, Jeong, Hong, Hwang, Kim, Yang, Ahn, Han, Kim: "Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood." in: Stem cells (Dayton, Ohio), Vol. 22, Issue 4, pp. 617-24, (2004) (PubMed).

    Wang, Marx, McNutt, Rutledge, Gown: "Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood." in: The American journal of pathology, Vol. 147, Issue 6, pp. 1799-810, (1996) (PubMed).

    Dias, Dilling, Houghton: "The molecular basis of skeletal muscle differentiation." in: Seminars in diagnostic pathology, Vol. 11, Issue 1, pp. 3-14, (1994) (PubMed).

  • 抗原
    Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
    别名
    Myogenin (MYOG 产品)
    别名
    cb553 antibody, zgc:100763 antibody, LOC446037 antibody, myf4 antibody, Xmyog antibody, myogenin antibody, LOC100136471 antibody, LOC100224062 antibody, LOC100303673 antibody, MYF4 antibody, bHLHc3 antibody, myo antibody, myf-4 antibody, myogenin antibody, myogenin (myogenic factor 4) antibody, MYOG antibody, myog antibody, LOC100303673 antibody, Myog antibody
    背景
    Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculin or Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Transfection of myogenin and other family members into a variety of non-muscle cells has been shown to either convert these cells to myogenic cells, or to transcriptionally activate a set of otherwise unexpressed muscle-specific genes. In addition to activating muscle-specific genes, members of the MyoD family members activate their own transcription and transactivate the transcription of other MyoD family members. For example, transfection of myogenin into 10T1/2 cells or Swiss 3T3 cells results in the activation of the endogenous myogenin gene as well as transactivation of MyoD. Likewise, the transfection of MyoD into these cells results in the activation of MyoD as well as the transactivation of myogenin. Each member of the MyoD family has distinct roles in muscle development, myogenin plays a key role in muscle maturation. Myogenin migrates at a molecular weight of ~34 kDa by SDS-PAGE. Clone F5D recognizes human, mouse, rat and cat myogenin. Mapping studies suggest that F5D reacts with an epitope between amino acids 138-158 of myogenin. A recombinant fusion protein corresponding to amino acids 30- 224 of rat myogenin was used as immunogen.
    分子量
    34 kDa
    途径
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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