SYNPO 抗体 (AA 495-509)
Quick Overview for SYNPO 抗体 (AA 495-509) (ABIN967124)
抗原
See all SYNPO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 495-509
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免疫原
- A synthetic peptide corresponding to a sequence at the middle region of human synaptopodin (495-509 aa), identical to the related mouse and rat sequence.
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限制
- 仅限研究用
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溶解方式
- 0.2ml of distilled water will yield a concentration of 500µg/ml.
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缓冲液
- Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
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储存液
- Thimerosal (Merthiolate), Sodium azide
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储存条件
- -20 °C
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: "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 6, pp. 2215-24, (2002) (PubMed).
: "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons." in: The Journal of comparative neurology, Vol. 418, Issue 2, pp. 164-81, (2000) (PubMed).
: "Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex." in: Nature, Vol. 183, Issue 4675, pp. 1592-3, (1959) (PubMed).
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: "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 6, pp. 2215-24, (2002) (PubMed).
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- SYNPO (Synaptopodin (SYNPO))
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别名
- Synaptopodin
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背景
- The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.
抗原
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