SCPA (C-Term) 抗体
There are 5+ publications for this product available. The 兔 多克隆 anti-SCPA antibody is suitable to detect SCPA in samples from Staphylococcus aureus. It has been validated for IHC.
(5 references)
产品编号 ABIN967004
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for SCPA (C-Term) 抗体 (ABIN967004)
抗原
SCPA
适用
Staphylococcus aureus
宿主
兔
克隆类型
多克隆
应用范围
Immunohistochemistry (IHC)
-
-
抗原表位
- C-Term
-
免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Bacteria: Staphylococcus aureus scpA (Staphylococcal cysteine proteinaseA)
-
-
-
限制
- 仅限研究用
-
-
-
储存条件
- 4 °C
-
-
-
: "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature." in: Nature communications, Vol. 13, Issue 1, pp. 7174, (2022) (PubMed).
: "Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells." in: PLoS pathogens, Vol. 17, Issue 9, pp. e1009874, (2021) (PubMed).
: "Genetic characterization of staphopain genes in Staphylococcus aureus." in: Biological chemistry, Vol. 385, Issue 11, pp. 1059-67, (2004) (PubMed).
: "A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus." in: Biochemistry, Vol. 42, Issue 46, pp. 13449-56, (2003) (PubMed).
: "Degradation of elastin by a cysteine proteinase from Staphylococcus aureus." in: The Journal of biological chemistry, Vol. 263, Issue 6, pp. 2664-7, (1988) (PubMed).
-
-
- SCPA
-
背景
-
The scpA (Staphylococcal cysteine proteinaseA) is able to degrade elastin. scpA (Staphylococcal cysteine proteinaseA) has a broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate. Prematurely activated/folded staphopain A is inhibited by staphostatin A (scpB), which is probably required to protect staphylococcal cytoplasmic proteins from degradation by scpA. In the cytoplasm, prematurely activated/folded scpA forms a stable non-covalent complex with scpB. Cleavage leads to the activation of scpA probably by an auto-catalytic manner. The catalytic maturation of scpA appears to reside outside the cascade of activation started by the metalloprotease aureolysin (aur) scpA (Staphylococcal cysteine proteinaseA) belongs to the peptidase C47 family.
Synonyms: sspP, sspB2, Staphopain A
抗原
-
You are here:
