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P-Cadherin 抗体 (AA 612-626)

This anti-P-Cadherin antibody is a 多克隆 antibody detecting P-Cadherin in WB, ICC 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN966724
发货至: 中国

Quick Overview for P-Cadherin 抗体 (AA 612-626) (ABIN966724)

抗原

See all P-Cadherin (CDH3) 抗体
P-Cadherin (CDH3)

适用

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宿主

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克隆类型

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多克隆

标记

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This P-Cadherin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 612-626

    免疫原

    A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.
  • 应用备注

    WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.

    限制

    仅限研究用
  • 溶解方式

    0.2ml of distilled water will yield a concentration of 500µg/ml.

    缓冲液

    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

    储存液

    Thimerosal (Merthiolate), Sodium azide

    储存条件

    -20 °C
  • Kaupmann, Becker-Follmann, Scherer, Jockusch, Starzinski-Powitz: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." in: Genomics, Vol. 14, Issue 2, pp. 488-90, (1992) (PubMed).

  • 抗原

    P-Cadherin (CDH3)

    别名

    P-Cadherin

    背景

    Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
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