Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) 抗体

ABIN966704 产品详细信息, 供应商: Log in to see
抗原
  • B23
  • NPM
  • NO38
  • Npm
  • B23NP
  • npm4
  • npm
  • CG7917
  • CRP1
  • Crp1
  • Dmel\\CG7917
  • dNLP
  • dNLP-S
  • p22
  • npm1
  • sb:cb487
  • nucleophosmin 1
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog
  • nucleophosmin 1b
  • Nucleophosmin
  • nucleophosmin
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • Nucleoplasmin
  • nucleophosmin 1a
  • NPM1
  • Npm1
  • npm1.L
  • npm1b
  • npm
  • Nlp
  • npm1a
适用
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宿主
小鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
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应用范围
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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选项
Supplier
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Supplier Product No.
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免疫原 Purified recombinant fragment of human NPM expressed in E. Coli.
克隆位点 7H10B9
亚型 IgG1
纯化方法 Ascitic fluid
抗原
别名 Nucleophosmin (NPM1 Antibody 摘要)
背景 Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Synonyms: B23, NPM
分子量 33kDa
基因ID 4869
途径 Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
应用备注 Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
限制 仅限研究用
状态 Liquid
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
有引用在: Yoneda-Kato, Look, Kirstein, Valentine, Raimondi, Cohen, Carroll, Morris: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." in: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

Morris, Kirstein, Valentine, Dittmer, Shapiro, Saltman, Look: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

背景 Bullrich, Morris, Hummel, Pileri, Stein, Croce: "Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas." in: Cancer research, Vol. 54, Issue 11, pp. 2873-7, 1994 (PubMed).

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