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LYN 抗体

LYN 适用: 人 ELISA Monoclonal 2H8D7 unconjugated
产品编号 ABIN966504
发货至: 中国
  • 抗原 See all LYN 抗体
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    适用
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    克隆类型
    • 126
    • 19
    单克隆
    标记
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    This LYN antibody is un-conjugated
    应用范围
    • 121
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    ELISA
    特异性
    Ni-NTA purified truncated recombinant Lyn expressed in E. Coli strain BL21 (DE3).
    纯化方法
    Antibodies are purified by protein A affinity chromatography
    免疫原
    Ni-NTA purified truncated recombinant Lyn expressed in E.coli strain BL21 (DE3)
    克隆位点
    2H8D7
    亚型
    IgG2b
    Top Product
    Discover our top product LYN Primary Antibody
  • 应用备注
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存条件
    -20 °C
  • Williams, Wierenga, Saraste: "Insights into Src kinase functions: structural comparisons." in: Trends in biochemical sciences, Vol. 23, Issue 5, pp. 179-84, (1998) (PubMed).

    Hibbs, Dunn: "Lyn, a src-like tyrosine kinase." in: The international journal of biochemistry & cell biology, Vol. 29, Issue 3, pp. 397-400, (1997) (PubMed).

  • 抗原
    LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
    别名
    LYN (LYN 产品)
    别名
    JTK8 antibody, p53Lyn antibody, p56Lyn antibody, lyn antibody, LYN antibody, AA407514 antibody, Hck-2 antibody, jtk8 antibody, lyn-A antibody, CH73-38P6.3 antibody, zgc:92124 antibody, LYN proto-oncogene, Src family tyrosine kinase antibody, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog antibody, tyrosine-protein kinase Lyn antibody, LYN proto-oncogene, Src family tyrosine kinase L homeolog antibody, LYN antibody, lyn antibody, Lyn antibody, LOC100593961 antibody, lyn.L antibody
    背景
    Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).
    基因ID
    4067
    途径
    Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
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