LCav2b (Isoform B) 抗体
This 兔 多克隆 antibody specifically detects LCav2b in IHC. It exhibits reactivity toward Great Pond Snail (Lymnaea stagnalis). It has been mentioned in 3+ publications
(3 references)
产品编号 ABIN966478
发货至:
中国
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Quick Overview for LCav2b (Isoform B) 抗体 (ABIN966478)
抗原
LCav2b
适用
Great Pond Snail (Lymnaea stagnalis)
宿主
兔
克隆类型
多克隆
应用范围
Immunohistochemistry (IHC)
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抗原表位
- Isoform B
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of Great Pond Snail (Lymnaea stagnalis) LCav2b (voltage-dependent non-L-type calcium channel alpha-1 subunit isoform b)
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限制
- 仅限研究用
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储存条件
- 4 °C
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: "Uncoupling of calcium channel alpha1 and beta subunits in developing neurons." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 41157-67, (2004) (PubMed).
: "Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 4258-67, (2003) (PubMed).
: "Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 21178-87, (2003) (PubMed).
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: "Uncoupling of calcium channel alpha1 and beta subunits in developing neurons." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 41157-67, (2004) (PubMed).
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- LCav2b
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背景
- LCav2b (voltage-dependent non-L-type calcium channel alpha-1 subunit isoform b) mediates entry of calcium ions into excitable cells. Calcium channel beta subunits are key modulators of calcium channel function and membrane targeting of the pore-forming alpha1 subunit. An invertebrate (Lymnaea stagnalis) homolog of P/Q- and N-type calcium channels (LCav2), although colocalized with beta subunits in synapses of mature neurons, is physically uncoupled from the beta subunits in the leading edge of growth cones of outgrowing neurons. LCav2 channels that mediate transmitter release in mature synapses also participate in neuronal outgrowth in growth cones. The differential association of beta subunits with synaptic calcium channels and those expressed in emergent neuronal growth shows that beta subunits may play a role in the transformation of Cav2 calcium channel function in immature neurons and mature synapses.
抗原
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