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GPC1 抗体 (C-Term)

Cited in 1 publication. This anti-GPC1 antibody is a 兔 多克隆 antibody detecting GPC1 in IHC. Suitable for 人 和 小鼠.
产品编号 ABIN966218
发货至: 中国
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Quick Overview for GPC1 抗体 (C-Term) (ABIN966218)

抗原

See all GPC1 抗体
GPC1 (Glypican 1 (GPC1))

适用

  • 72
  • 21
  • 15
人, 小鼠

宿主

  • 78
  • 9
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  • 2

克隆类型

  • 68
  • 25
  • 1
多克隆

标记

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This GPC1 antibody is un-conjugated

应用范围

  • 44
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  • 18
  • 15
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Immunohistochemistry (IHC)
  • 抗原表位

    • 15
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    • 1
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    C-Term

    纯化方法

    Purified by antigen-specific affinity chromatography.

    免疫原

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human GPC1(Glypican-1 precursor)
  • 应用备注

    ELISA, Western blotting: 1µg/ml for 2hrs.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    This antibody is stored in PBS, 50% glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Davies, Blackhall, Shanks, David, McGown, Swindell, Slade, Martin-Hirsch, Gallagher, Jayson: "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 15, pp. 5178-86, (2004) (PubMed).

  • 抗原

    GPC1 (Glypican 1 (GPC1))

    别名

    GPC1

    背景

    GPC1(Glypican-1) is a cell surface proteoglycan that bears heparan sulfate. The protein is attached to the membrane by a GPI-anchor. This cell-associated glypican is further processed to give rise to a medium-released species. The glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. The syndecan-1 and glypican-1 have roles in progression of ovarian cancer. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

    途径

    Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation
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