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FOXO1 抗体

This anti-FOXO1 antibody is a 兔 多克隆 antibody detecting FOXO1 in IHC. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN966149
发货至: 中国

Quick Overview for FOXO1 抗体 (ABIN966149)

抗原

See all FOXO1 抗体
FOXO1 (Forkhead Box O1 (FOXO1))

适用

  • 228
  • 167
  • 144
  • 48
  • 30
  • 25
  • 18
  • 11
  • 9
  • 8
  • 7
  • 4
  • 2
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 210
  • 21
  • 1

克隆类型

  • 199
  • 33
多克隆

标记

  • 106
  • 10
  • 9
  • 8
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
This FOXO1 antibody is un-conjugated

应用范围

  • 187
  • 91
  • 78
  • 69
  • 59
  • 58
  • 39
  • 32
  • 21
  • 20
  • 7
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
Immunohistochemistry (IHC)
  • 特异性

    FKHR (Ab-319) antibody detects endogenous levels of total FKHR protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    免疫原

    The antiserum was produced against synthesized non-phosphopeptide derived from human FKHR around the phosphorylation site of serine 319.
  • 应用备注

    WB: 1:500~1:1000
    IHC: 1:50~1:100.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100ug/100ul.

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Zhao, Gan, Pan, Kan, Majeski, Adam, Unterman: "Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms." in: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 839-49, (2004) (PubMed).

    Rena, Woods, Prescott, Peggie, Unterman, Williams, Cohen: "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion." in: The EMBO journal, Vol. 21, Issue 9, pp. 2263-71, (2002) (PubMed).

    Rena, Prescott, Guo, Cohen, Unterman: "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting." in: The Biochemical journal, Vol. 354, Issue Pt 3, pp. 605-12, (2001) (PubMed).

    Guo, Rena, Cichy, He, Cohen, Unterman: "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 17184-92, (1999) (PubMed).

  • 抗原

    FOXO1 (Forkhead Box O1 (FOXO1))

    别名

    FKHR

    途径

    PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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