DISC1 抗体 (C-Term)
(5 references)Quick Overview for DISC1 抗体 (C-Term) (ABIN965998)
抗原
See all DISC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Purified by antigen-specific affinity chromatography.
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DISC1(Disrupted in schizophrenia 1 protein)
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anti-Disrupted in Schizophrenia 1 (DISC1) (AA 102-261) antibody
DISC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) antibodyDISC1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 1-200) antibodyDISC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 99-325) antibodyDISC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 461-477), (Middle Region) antibodyDISC1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 151-330) antibodyDISC1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 700-728), (C-Term) antibodyDISC1 适用: 人 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 101-200) antibodyDISC1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 761-832) antibodyDISC1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (N-Term) antibodyDISC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- This antibody is stored in PBS, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).
: "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." in: Human molecular genetics, Vol. 12, Issue 13, pp. 1591-608, (2003) (PubMed).
: "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 1, pp. 289-94, (2003) (PubMed).
: "Disruption of two novel genes by a translocation co-segregating with schizophrenia." in: Human molecular genetics, Vol. 9, Issue 9, pp. 1415-23, (2000) (PubMed).
: "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 4, Issue 5, pp. 345-9, (1998) (PubMed).
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: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).
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- DISC1 (Disrupted in Schizophrenia 1 (DISC1))
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别名
- DISC1 (Disrupted in schizophrenia 1 protein)
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背景
- DISC1 (Disrupted in schizophrenia 1 protein) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is involved in neurite outgrowth and cortical development through its interaction with other proteins. DISC1 interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. The interaction with microtubules may be mediated in part by TRAF3IP1. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1,11)(q42.1,q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.
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途径
- Regulation of Cell Size
抗原
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